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Iron Acquisition by the Genus Mycobacterium : History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

Author: B Rowe Byers
Publisher: Heidelberg : Springer International Publishing : Springer e-books : Imprint: Springer : Springer e-books, 2013.
Series: Biomedical and Life Sciences (Springer-11642); Springer briefs in molecular science (Print)
Edition/Format:   Computer file : EnglishView all editions and formats
Database:WorldCat
Summary:
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are  Read more...
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Additional Physical Format: Iron Acquisition by the Genus Mycobacterium [Texte imprimé]
9783319003023
Document Type: Computer File
All Authors / Contributors: B Rowe Byers
ISBN: 9783319003030 3319003038
OCLC Number: 871539841
Description: 1 online resource.
Details: Nécessite un lecteur de fichier PDF.
Contents: A History of Iron Metabolism in the Mycobacteria --
Mycobacterial Iron Uptake Mechanisms --
Siderocalin Combats Mycobacterial Infections --
Design of Anti-TB Drugs Using the Iron Uptake Platform
Series Title: Biomedical and Life Sciences (Springer-11642); Springer briefs in molecular science (Print)
Responsibility: edited by B. Rowe Byers.

Abstract:

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

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