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Kinase inhibitors : methods and protocols

Author: Bernhard Kuster
Publisher: New York : Humana Press : Springer, ©2012.
Series: Methods in molecular biology (Clifton, N.J.), v. 795.; Springer protocols (Series)
Edition/Format:   Print book : Document   Computer File : EnglishView all editions and formats
Summary:

In this Methods in Molecular Biology (TM) volume, experts in kinase biology, drug discovery and clinical research present exemplary methods for addressing the challenges involved in discovery and  Read more...

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Genre/Form: Laboratory Manuals
Material Type: Document, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Bernhard Kuster
ISBN: 9781617793363 1617793361 9781617793370 161779337X
OCLC Number: 762431648
Description: xi, 256 pages : illustrations (some color) ; 27 cm.
Contents: Targeting cancer with small-molecular-weight kinase inhibitors / Doriano Fabbro [and others] --
Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation / Matthias Gaestel and Alexey Kotlyarov --
Measuring the activity of leucine-rich repeat kinase 2 : a kinase involved in Parkinson's disease / Byoung Dae Lee [and others] --
Measuring P13K lipid kinase activity / Elisa Ciraolo, Alessia Perino, and Emilio Hirsch --
A fluorescence polarization assay for the discovery of inhibitors of the polo-box domain of polo-like kinase 1 / Wolfgang Reindl, Klause Strebhardt, and Thorsten Berg --
Assessment of hepatotoxicity potential of drug candidate molecules including kinase inhibitors by hepatocyte imaging assay technology and bile flux imaging assay technology / Jinghai J. Xu [and others] --
Kinase inhibitor selectivity profiling using differential scanning fluorimetry / Oleg Fedorov, Frank H. Niesen, and Stefan Knapp --
Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP / James S. Duncan, Timothy A.J. Haystead, and David W. Litchfield --
Proteome-wide identification of staurosporine-binding kinases using capture coumpound mass spectrometry / Jenny J. Fischer, Olivia Y. Graebner (neé Baessler), and Mathias Dreger --
Affinity pruification of proteins binding to kinase inhibitors immobilized on self-assembling monolayers / Marcus Bantscheff, Scott Hobson, and Bernhard Kuster --
Kinase inhibitor profiling using chemoproteomics / Markus Schirle [and others] --
Covalent cross-linking of kinases with their corresponding peptide substrates / Alexander V. Statsuk and Kevan M. Shokat --
Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays / Oliver Pötz [and others] --
Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays / Gabriela Lavezzari and Mark R. Lackner --
Measuring phosphorylation-specific changes in response to kinase inhibitors in mammalian cells using quantitative proteomics / Nurhan Özlü, Marc Kirchner, and Judith Jebanathirajah Steen --
Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays / Kian Kani, Rafaella Sordella, and Parag Mallick.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 795.; Springer protocols (Series)
Responsibility: edited by Bernhard Kuster.

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From the reviews:"This well-organized book is highly recommended to those who are interested in kinase inhibitors in both basic research and clinical practice. It is intended to provide an easily Read more...

 
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