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The kinetochore : from molecular discoveries to cancer therapy

Author: Peter De Wulf; William C Earnshaw
Publisher: New York : Springer, ©2009.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:
"Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Peter De Wulf; William C Earnshaw
ISBN: 9780387690735 0387690735
OCLC Number: 298595281
Description: xiii, 509 pages : illustrations (some color) ; 24 cm
Contents: Centromeres and kinetochores : an historical perspective / Kerry S. Bloom --
The basics of chromosome segregation / Mitsuhiro Yanagida --
The centromere / Beth A. Sullivan --
Neocentromeres / Owen J. Marshall and K.H. Andy Choo --
Human artificial centromeres : de novo assembly of functional centromeres on human artificial chromosomes / Hiroshi Masumoto, Teruaki Okada, and Yasuhide Okamoto --
Kinetochore composition, formation, and organization / Tatsuo Fukagawa and Peter De Wulf --
Evolution of centromeres and kinetochores : a two-part fugue / Paul B. Talbert, Joshua J. Bayes, and Steven Henikoff --
Mitotic spindle assembly mechanisms / Rebecca Heald and Claire E. Walczak --
Kinetochore-microtubule interactions / Lesley Clayton and Tomoyuki U. Tanaka --
Post-translational modifications that regulate kinetochore activity / Chitra V. Kotwaliwale and Sue Biggins --
The role of the kinetochore in spindle checkpoint signaling / P. Todd Stukenberg and Daniel J. Burke --
Kinetochore regulation of anaphase and cytokinesis / Scott Thomas and Kenneth B. Kaplan --
Roles of centromeres and kinetochores in meiosis / Adele L. Marston --
The kinetochore-cancer connection / Takeshi Tomonaga --
The kinetochore as target for cancer drug development / Song-tao Liu and Tim J. Yen.
Responsibility: Peter De Wulf, William C. Earnshaw, editors.
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Abstract:

Kinetochores are being mined as a rich target for the next generation of anti-cancer drugs. This book presents a thorough analysis of kinetochore and centromere composition, formation, regulation,  Read more...

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   schema:reviewBody ""Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs."--Jacket." ;
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