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Label-Free Biosensing : Advanced Materials, Devices and Applications

Author: Michael J Schöning; Arshak Poghossian
Publisher: Cham, Switzerland : Springer, [2018] ©2018
Series: Springer series on chemical sensors and biosensors, 16.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry  Read more...
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Genre/Form: Electronic books
Additional Physical Format: (OCoLC)1019610961
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Michael J Schöning; Arshak Poghossian
ISBN: 9783319752204 3319752200
OCLC Number: 1045629731
Description: 1 online resource.
Contents: Intro; Series Editor; Aims and Scope; Preface; Contents; Nanomaterial-Modified Capacitive Field-Effect Biosensors; 1 Introduction; 2 Capacitive EIS Sensors Modified with AuNP/Molecule Hybrids; 2.1 Preparation of AuNP-Modified EIS Sensors and Measurement Setup; 2.2 Functioning of EIS Sensors Modified with AuNP/Molecule Hybrids; 2.3 Detection of Cytochrome c; 2.4 Detection of Poly-d-lysine; 2.5 Detection of LbL Adsorption of Oppositely Charged PE Macromolecules and Multilayer Formation; 2.6 Enzyme Logic Gates Based on an AuNP-Modified EIS Sensor; 3 Polyelectrolyte-Modified EIS Sensors 3.1 Label-Free Detection of DNA with PAH-Modified EIS Sensor3.2 Biosensors Based on an EIS Sensor Modified with a PAH/Enzyme Multilayer; 4 Summary and Outlook; References; Silicon Nanowire Field-Effect Biosensors; 1 Introduction: Ion-Sensitive Field-Effect Transistors; 2 Sensor Operation and Readout Strategies; 2.1 Surface-Charge Sensing; 2.2 Beyond Surface-Charge Sensing; 3 Silicon Nanowire Ion-Sensitive Field-Effect Transistors; 3.1 Fabrication of SiNW ISFETs; 3.2 Limitations of SiNW-based ISFETs; 3.2.1 Downscaling of ISFETs; 3.2.2 Surface Functionalization 3.2.3 Gate Oxide and Sensor Configuration3.2.4 Sensing in Physiological Solutions; 4 Competing Platforms and New Concepts; 4.1 New Materials and Nanowire Hybrids; 4.2 Microfluidic Integration; 5 Conclusions; References; Label-Free Biosensors Based on III-Nitride Semiconductors; 1 Introduction; 2 Group III-Nitrides; 2.1 Basic Properties; 2.2 Polarization in Group III-Nitrides; 2.3 Indium Nitride; 2.4 Summary of Features Relevant for Biosensors; 2.5 Overview on Nitride-Based Biosensors; 3 High-Electron-Mobility Transistor Sensors; 3.1 Sensor Structure and Technology; 3.2 pH Sensors 3.3 Monitoring Biochemical Reactions4 Surface Treatment and Stability; 4.1 Oxidation; 4.2 Stability in Water; 4.3 Cleaning of GaN Surfaces; 4.4 Wetting Behavior; 4.5 Impact of Device Processing; 5 Biofunctionalization of the Surfaces; 6 BioFETs (Detection of Biomarkers); 6.1 Enzyme-Modified Sensor: EnFET; 6.2 Immunologically Based Sensor: ImmunoFET; 6.3 DNA-Modified Sensor: DNA-FET; 6.4 Advanced Measurement Schemes; 6.4.1 Subthreshold Operation; 6.4.2 Impedance Spectroscopy; 6.4.3 Dynamic Measurements; 7 Cell Proliferation; 8 Cell-FETs (Monitoring Living Cells); 9 Further Biosensors 9.1 Electrical Biosensors: Nanowires9.2 Mechanical Biosensors: Electroacoustic Resonators; 9.3 Optical Biosensors; 10 Multiparameter Systems; 11 Conclusions; References; (Bio-)chemical Sensing and Imaging by LAPS and SPIM; 1 Introduction; 2 Principles of LAPS and SPIM; 2.1 Measurement Set-Up; 2.2 Generation of Photocurrent Dependent on Analyte Concentration; 2.3 Photocurrent-Voltage and Phase-Voltage Characteristics; 2.4 Equivalent Circuit of the LAPS; 2.5 Operation Modes; 2.5.1 Constant-Bias Mode; 2.5.2 Constant-Current Mode; 2.5.3 Potential-Tracking Mode; 2.5.4 Phase Mode; 2.5.5 SPIM Mode
Series Title: Springer series on chemical sensors and biosensors, 16.
Responsibility: volume editors, Michael J. Schöning, Arshak Poghossian ; with contributions by N. Abramova [and others].

Abstract:

"This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with:·       semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors·       impedimetric biosensors using planar and 3D electrodes·       nanocavity and solid-state nanopore devices ·       carbon nanotube and graphene/graphene oxide biosensors·       electrochemical biosensors using molecularly imprinted polymers·       biomimetic sensors based on acoustic signal transduction·       enzyme logic systems and digital biosensors based on the biocomputing concept·       heat-transfer as a novel transducer principle·       ultrasensitive surface plasmon resonance biosensors ·       magnetic biosensors and magnetic imaging devices"--

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