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Labelling of small biomolecules using novel technetium-99m cores.

Author: International Atomic Energy Agency.
Publisher: Vienna, Austria : International Atomic Energy Agency, 2007.
Series: Technical reports series (International Atomic Energy Agency), no. 459.
Edition/Format:   Print book : International government publication : EnglishView all editions and formats
Database:WorldCat
Summary:
Technetium-99m radiopharmaceuticals account for nearly 80% of all diagnostic studies done in nuclear medicine. The ability to determine the exact molecular structure of the coordination compounds by using modern powerful analytical tools such as NMR, mass spectroscopy and X ray diffraction has contributed to the understanding of the structure-activity relationships underlying the biological behavior of Tc-99m  Read more...
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Details

Genre/Form: Laboratory Manuals
Material Type: Government publication, International government publication, Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: International Atomic Energy Agency.
ISBN: 9789201016072 9201016077
OCLC Number: 191954428
Notes: "STI/DOC/010/459"--Title page verso.
Description: 311 pages : illustrations ; 24 cm.
Contents: pt. 1. Overview of the coordinated research project --
pt. 2. Reports by the participants in the coordinated research project.
Series Title: Technical reports series (International Atomic Energy Agency), no. 459.

Abstract:

Technetium-99m radiopharmaceuticals account for nearly 80% of all diagnostic studies done in nuclear medicine. The ability to determine the exact molecular structure of the coordination compounds by using modern powerful analytical tools such as NMR, mass spectroscopy and X ray diffraction has contributed to the understanding of the structure-activity relationships underlying the biological behavior of Tc-99m agents. Consequently, careful design of new ligands and their Tc-99m complexes led to the discovery of imaging agents for perfusion in the myocardium and brain, thereby extending the scope of diagnostic imaging using Tc-99m radiopharmaceuticals. Based on the new developments in Tc chemistry, there is good scope for the development of new radiopharmaceuticals for imaging cancer as well as certain specific disease conditions. The IAEA organized a Coordinated Research Project (CRP) with the specific objective to develop labelled biomolecules with the novel Tc-99m metal cores such as the Tc-99m-Carbonyl, Tc-99m-Nitrido, Tc-99m (4+1) and Tc-99m-HYNIC cores. The preparation, quality assessment and biological evaluations of a large number of Tc-99m complexes with biomolecules such as RGD peptides, annexin derived peptides, fatty acid derivatives, quinazoline derivatives and glucose analogues were achieved by the participants during the CRP. The results obtained from the participating laboratories are summarized in this publication.--Publisher's description.

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