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Lead generation : methods, strategies, and case studies

Author: Jörg Holenz
Publisher: Weinheim, Germany : Wiley-VCH, 2016.
Series: Methods and principles in medicinal chemistry.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Lead generation : methods, strategies, and case studies.
Weinheim, Germany : Wiley-VCH, ©2016
979 pages
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jörg Holenz
ISBN: 9783527677047 3527677046 9783527677061 3527677062
OCLC Number: 950467475
Description: 1 online resource.
Contents: Introduction to Lead Generation. Introduction: Learnings from the Past : Characteristics of Successful Leads / Mike Hann --
Modern Lead Generation Strategies / Jörg Holenz, Dean G Brown --
The Importance of Target Identification for Generating Successful Leads. "Ligandability" of Drug Targets: Assessment of Chemical Tractability via Experimental and Approaches / Udo Bauer, Alexander L Breeze --
Chemistry-Driven Target Identification / Iván Cornella-Taracido, Ryan Hicks, Ola Engkvist, J Adam Hendricks, Ronald Tomlinson, M Paola Castaldi --
Hit Generation Methods. Lead Generation Based on Compound Collection Screening / Dirk Weigelt, Ismet Dorange --
Fragment-Based Lead Generation / Ivan V Efremov, Daniel A Erlanson --
Rational Hit Generation / Bernd Wellenzohn, Alexander Weber --
Competitive Intelligence-based Lead Generation and Fast Follower Approaches / Yu Jiang, Ziping Liu, Jörg Holenz, Hua Yang --
Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation / Norbert Handler, Andrea Wolkerstorfer, Helmut Buschmann --
Lead Generation for Challenging Targets / Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian-Hui Wu Xuemin Cheng, Jin Li --
Collaborative Approaches to Lead Generation / Fabrizio Giordanetto, Anna Karawajczyk, Graham Showell --
Converting Hits to Successful Leads. A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery / Dean G Brown --
Molecular Recognition and Its Importance for Fragment-Based Lead Generation and Hit-to-Lead / Thorsten Nowak --
Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase / Stefan Geschwindner --
Predictive Methods in Lead Generation / Matthew D Segall, Peter Hunt --
Lead Quality / J Willem M Nissink, Sebastien Degorce, Ken Page --
Hypothesis-driven Lead Optimization. The Strategies and Politics of Successful Design, Make, Test, and Analyze (DMTA) Cycles in Lead Generation / Steven S Wesolowski, Dean G Brown --
Recent Lead Generation Success Stories. Lead Generation Paved the Way for the Discovery of a Novel H Inverse Agonist Clinical Candidate / Christophe Genicot, Laurent Provins --
Vorapaxar: From Lead Identification to FDA Approval / Samuel Chackalamannil, Mariappan Chelliah --
Lead Generation Approaches Delivering Inhaled [beta]-Adrenoreceptor Agonist Drug Candidates / Michael Stocks, Lilian Alcaraz --
GPR81 HTS Case Study / Eric Wellner, Ola Fjellström --
Development of Influenza Virus Sialidase Inhibitors / Mauro Pascolutti, Robin J Thomson, Mark von Itzstein --
The Discovery of Cathepsin A Inhibitors: A Project-Adapted Fragment Approach Based on HTS Results / Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Dominik Linz, Hartmut Rütten, Georg Horstick, Markus Kohlmann, Katja Kroll, Klaus Wirth, Thorsten Sadowski --
Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery / Jeremy N Burrows, Takushi Kaneko --
A Fragmentation Enumeration Approach to Generating Novel Drug Leads / Pravin S Iyer, Manoranjan Panda.
Series Title: Methods and principles in medicinal chemistry.
Responsibility: edited by Jörg Holenz.

Abstract:

The complete picture of methods and strategies in industrial and academic lead finding and optimization, covering standard as well as novel approaches and highlighting their strengths and weaknesses.  Read more...

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"it is certainly the most comprehensive and up-to-date resource currently available on the topic.."....."is an excellent resource for any scientist working in lead generation.."....."This is a Read more...

 
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