Pilot Rayford Steele is flying his 747 to London and contemplating whether or not to commit adultery when a flight attendant gives him some frightening news. Some of their passengers have disappeared into thin air, leaving only their clothing as a sign that they ever existed. After the flight crew does a head count, they realize more than 100 people are missing. One passenger still on the plane is reporter Buck Williams, whose recent experiences and witnessing of some strange events in Israel have led him to rethink his own lack of religious faith. As word comes that the entire world is suffering from disappearances, as well as horrifying natural disasters, Steele and Williams soon realize they, and the rest of the world, are experiencing the "Rapture of the Saints."