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Lesions and transplantation

Author: P Michael Conn
Publisher: San Diego, Calif. : Academic Press, [1991] ©1991
Series: Methods in neurosciences, v. 7.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Methods in Neurosciences, Volume 7: Lesions and Transplantation describes the chemical and nonchemical production of lesions and preparation and development of transplants, implants, and grafts. This book consists of four sections-chemical and nonchemical lesioning; model systems utilizing lesioning; transplants, implants, and grafts; and assessment of lesions and transplants. In these sections, this volume  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Lesions and transplantation
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: P Michael Conn
ISBN: 9781483259505 1483259501
OCLC Number: 881472647
Description: 1 online resource (xvii, 496 pages) : illustrations.
Contents: Front Cover; Lesions and Transplantation; Copyright Page; Table of Contents; Preface; Methods in Neurosciences; Section I: Chemical and Nonchemical Lesioning; Chapter 1. Lesioning of Rat Nigrostriatal Dopamine Pathway with l-Methyl-4-phenylpyridinium Ion (MPP+); Introduction; Methods; Evaluation of the Lesion; Conclusion; References; Chapter 2. Excitotoxins as Tools for Producing Brain Lesions; Introduction; Excitotoxins: Classification, Comparison, and Mechanisms; Use of Excitotoxins to Make Lesions; Summary; Acknowledgments; References; Chapter 3. Excitotoxin-Lesioned Rat Striatum; Methods AcknowledgmentsReferences; Chapter 4. Use of Acromelic Acid for Production of Rat Spinal Lesions ; Acromelic Acid; Injection of Acromelic Acid into Rats and Mice; Kainoid Neurotoxicity; Electrophysiological and Pharmacological Basis; Behavioral Basis; Histological Basis; References; Chapter 5. Use of Ibotenic Acid to Selectively Lesion Brain Structures ; Methods and Procedures; Additional Considerations; Is There Damage to Fibers of Passage following IBO Injections?; Conclusions; Acknowledgments; References; Chapter 6. Monosodium Glutamate (MSG) Lesions; Introduction; Mechanism of Action Histology of LesionsProcedures; MSG Syndrome; Histochemical Changes; Summary; References; Chapter 7. Comparison of Electrolytic and Radio-Frequency Lesion Methods; Introduction and Historical Background; Different Effects Observed with Electrolytic and Radio-Frequency Lesions; Production of Electrolytic Lesions; Production of Radio-Frequency Lesions; Production and Verification of Lesions That Leave No Metallic Ion Deposits; Summary and Conclusion; References; Chapter 8. Use of Cold to Reversibly Suppress Local Brain Function in Behaving Animals ; Moveable Cryodes Permanently Implanted CryodesAcknowledgment; References; Chapter 9. Chorioretinal Photocoagulation by Different Laser Sources; Introduction; Photocoagulation; Laser Power; Exposure Time; Spot Size; Laser Photocoagulators; Transpupillary Photocoagulation; Transscleral Photocoagulation; Endoocularphotocoagulation; References; Chapter 10. Production of Reversible Local Blockage of Neuronal Function; Introduction; Local Cooling of the CNS; Local Anesthesia; Other Chemicals; Summary; References; Chapter 11. Lesioning the Nucleus Basalis; Introduction; Lesioning Methods; Conclusions; References Section II: Model Systems Utilizing LesioningChapter 12. Unilateral MPTP-Lesioned Monkey as an Animal Model for Parkinson's Disease; Parkinson's Disease; 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP); Bilateral versus Unilateral MPTP-Treated Monkeys; MPTP Application; The Unilateral MPTP-Lesioned Monkey; Conclusions; Acknowledgments; References; Chapter 13. MPTP-Induced Parkinsonism in Nonhuman Primates ; Species; MPTP Administration; Clinical Outcome of MPTP Administration; Histological Changes after MPTP Administration; Neurochemical Changes after MPTP Administration
Series Title: Methods in neurosciences, v. 7.
Responsibility: edited by P. Michael Conn.


This volume describes recent techniques used in neuropeptide technology, for example, in the identification and purification of neuropeptides, in neuropeptide synthesis, the identification of  Read more...
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