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LHRH and Its Analogs : Contraceptive and Therapeutic Applications Part 2

Author: B H Vickery; J J Nestor
Publisher: Dordrecht : Springer Netherlands, 1987.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Since the discovery of LHRH in 1971, research into the physiology and therapeutics of this compound can be divided into three dis tinctly different phases. In the first phase, attention was paid chiefly to the natural sequence hormone; efforts were channeled to explore its diagnostic use; and nearly all the clinical investigations were coordinated by a single pharmaceutical company. The successes in this area were  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: B H Vickery; J J Nestor
ISBN: 9789400932296 9400932294
OCLC Number: 851373379
Description: 1 online resource (656 pages)
Contents: Section 1 Chemistry --
1. Development of LHRH antagonists --
2. LHRH antagonists with low histamine releasing activity --
3. Specificity of design to achieve antagonists of LHRH of increasing effectiveness in therapeutic activity --
4. Biosynthesis of LHRH --
5. Phylogenetic diversity of LHRH --
Section 2 Mechanisms of Action of Hypothalamic LHRH and Analogs --
6. Molecular mechanism of LHRH action in the gonadotrope --
7. Mediation of the preovulatory LH surge: LHRH pulsatility and opioid modulation --
Section 3 Extra-Hypothalamic LHRH-Like Materials --
8. LHRH binding sites in human tissues --
9. LHRH and 'LHRH-like' factors in the male reproductive tract --
10. Placental LHRH-like activity --
Section 4 Pharmacology of LHRH Antagonists --
11. In vitro histamine release with LHRH analogs --
12. Anaphylactoid properties of LHRH analogs --
13. Reproductive physiology and general pharmacology of LHRH antagonists --
14. Suppression of plasma gonadotropins, testosterone and sperm production in adult male monkeys by a potent inhibitory analog of LHRH --
15. LHRH antagonists and female reproductive function --
Section 5 Basic Clinical Studies --
16. LHRH antagonists in normal men --
17. Clinical investigations of the contraceptive and therapeutic potential of nafarelin --
18. LHRH agonists and antagonists: therapeutic possibilities for premenstrual syndrome --
19. Early clinical studies with LHRH antagonists in women --
20. Profertility uses of LHRH agonist analogues --
Section 6 Clinical Trials --
21. Ovulation induction with pulsatile LHRH --
22. Treatment of endometriosis by nasal administration of nafarelin --
23. Effects of nafarelin in precocious puberty --
24. Pharmacokinetics, metabolism and clinical studies with buserelin --
25. Trials with leuprolide --
26. Zoladex studies in prostatic and breast cancer --
27. Intermittent LHRH agonist sequentially combined with a progestogen as antiovulatory contraception --
28. LHRH agonists and male contraception --
Section 7 Gonadal Protective Prospects with LHRH Analogs --
29. Interactions between an LHRH analogue and cancer chemotherapeutic agents at the testicular level in dogs --
30. Is it possible to conserve the fertility of patients with Hodgkin's disease treated with cytotoxic chemotherapy? --
Section 8 Diagnostic Applications --
31. Predicting predisposition to osteoporosis: GnRH antagonist for acute estrogen deficiency --
Section 9 Applications in Animals --
32. The use of LHRH analogs in aquaculture --
33. Uses of LHRH and its analogs in cattle --
34. Clinical uses of LHRH analogs in dogs --
Section 10 Formulation and Metabolism --
35. Intra-nasal administration of LHRH and its analogs --
36. The controlled delivery of polypeptides including LHRH analogs --
37. Pharmacokinetics and metabolism of LHRH analogs --
Epilogue.
Responsibility: edited by B.H. Vickery, J.J. Nestor.

Abstract:

Since the discovery of LHRH in 1971, research into the physiology and therapeutics of this compound can be divided into three dis- tinctly different phases. A second theme which emerged during this  Read more...

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