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Ligand design in medicinal inorganic chemistry

Author: Tim Storr
Publisher: Chichester, West Sussex : Wiley, 2014.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to  Read more...

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Additional Physical Format: Online version:
Ligand design in medicinal inorganic chemistry.
Chichester, West Sussex : John Wiley & Sons Inc., 2014
(DLC) 2013051083
Document Type: Book
All Authors / Contributors: Tim Storr
ISBN: 9781118488522 1118488520
OCLC Number: 866766663
Description: xvii, 449 pages : illustrations ; 26 cm
Contents: Introduction to ligand design in medicinal inorganic chemistry --
Platinum-based anticancer agents --
Coordination chemistry and ligand design in the development of metal based radiopharmaceuticals --
Ligand design in D-block optical imaging agents and sensors --
Luminescent lanthanoid probes --
Metal complexes of carbohydrate-targeted ligands in medicinal inorganic chemistry --
Design of Schiff base-derived ligands: applications in therapeutics and medical diagnosis --
Metal-based antimalarial agents --
Therapeutic gold compounds --
Ligand design to target and modulate metal-protein interactions in neurodegenerative diseases --
Rational design of copper and iron chelators to treat Wilson's disease and hemochromatosis --
MRI contrast agents --
Photoactivatable metal complexes and their use in biology and medicine --
Metalloprotein inhibitors --
Ruthenium anticancer compounds with biologically-derived ligands.
Responsibility: edited by Tim Storr, Department of Chemistry, Simon Fraser University, Burnaby, Canada.
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