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Local Anesthetics

Author: Gary R Strichartz
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1987.
Series: Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, 81.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

Local anesthetics are among the most widely used drugs. Relief of acute pain, accompanying dental manipulations, for example, and of chronic pain are also accomplished with traditional local  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gary R Strichartz
ISBN: 9783642711107 3642711103
OCLC Number: 851775369
Description: 1 online resource (52 illustrations).
Contents: 1 Some Aspects of the History of Local Anesthesia --
A. Introduction --
B. Freud, Koller and the Early History of Cocaine --
C. Structure and Synthesis of Local Anesthetics --
D. Epinephrine and Local Anesthesia --
E. Toxicity of Local Anesthetics --
F. The Nervous Impulse and the Action of Local Anesthetics --
G. Pharmacokinetics of Local Anesthetics --
H. Summary and Conclusions --
References --
2 The Action of Local Anesthetics on Ion Channels of Excitable Tissues --
A. Introduction --
B. Physiological Basis of Generation of the Action Potential --
C. The Action of Local Anesthetics on Sodium Channels --
D. Current Questions in Local Anesthetic Action --
E. New Kinds of Local Anesthetic Agents --
F. Effects of Local Anesthetics on Potassium Channels --
G. Conclusion --
References --
3 Structural Elements which Determine Local Anesthetic Activity --
A. Introduction --
B. Structure and Physico-Chemical Properties of Local Anesthetics --
C. Resolution of Structural Contributions to Potency --
D. Comparisons of Nerve Blocking Actions with Antiarrhythmic Actions of Local Anesthetics --
E. Models for Local Anesthetic Receptors --
References --
4 Mechanisms of Differential Nerve Block --
A. Introduction --
B. Historical Discussion --
C. Confirmations, Extensions, Clarifications, and Contradictions --
D. Summary and Conclusion --
References --
5 Pharmacokinetics of Local Anesthetics --
A. Introduction --
B. Factors Affecting the Interpretation of Local Anesthetic Blood Concentrations --
C. Metabolism --
D. Pharmacokinetics in Man --
E. Factors Affecting Pharmacokinetics of Local Anesthetics --
F. Pharmacokinetics in Experimental Animals --
References --
6 Toxicity and Systemic Effects of Local Anesthetic Agents --
A. Effects on the Central Nervous System --
B. Effects on the Cardiovascular System --
C. Effects on the Neuromuscular Junction --
D. Miscellaneous Effects --
E. Other Toxicological Effects --
F. Treatment of Systemic Toxicity --
G. Local Tissue Toxicity --
H. Summary --
References --
7 The Role of Local Anesthetic Effects in the Actions of Antiarrhythmic Drugs --
A. Introduction --
B. Electrophysiology of Cardiac Fibers --
C. The Effects of Local Anesthetics on Cardiac Fibers --
D. Antiarrhythmic Effects of Local Anesthetic Agents --
E. Conclusion --
References --
8 Central Effects of Local Anesthetic Agents --
A. Introduction --
B. Routes of Entry of Local Anesthetic Agents into the CNS --
C. Behavioral Pharmacology of Local Anesthetic Agents --
D. Effects of Local Anesthetics on Electrical Activity of the Brain --
E. Anticonvulsant Properties of Local Anesthetics --
F. Temporal and Spatial Effects of Local Anesthetics at Regional CNS Sites --
G. The Mechanisms Underlying Local Anesthetic-Induced Seizures --
H. Central Nervous System Metabolic Effects of Local Anesthetics --
I. Summary --
References.
Series Title: Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, 81.
Responsibility: edited by Gary R. Strichartz.

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