跳到内容
Long-Term Consequences of Drugs on the Paediatric Cardiovascular System
关闭预览资料
正在查...

Long-Term Consequences of Drugs on the Paediatric Cardiovascular System

著者: Elizabeth HausnerMonica FiszmanJoseph HanigPatricia HarlowGwen Zornberg所有著者
出版商: Adis International Limited
版本/格式: 文章 文章 : 英语
刊登在:Drug Safety, 31, no. 12 (2008): 1083-1096
数据库:ArticleFirst
其它数据库: WorldCatElsevierBritish Library Serials
评估:

(尚未评估) 0 附有评论 - 争取成为第一个。

更多类似这样的

 

&AllPage.SpinnerRetrieving;

在图书馆查找

&AllPage.SpinnerRetrieving; 正在查找有这资料的图书馆...

详细书目

文件类型: 文章
所有的著者/提供者: Elizabeth Hausner; Monica Fiszman; Joseph Hanig; Patricia Harlow; Gwen Zornberg; Solomon Sobel
ISSN:0114-5916
语言注释: English
专有的标识符 365863444
奖励:

评论

用户提供的评论
正在获取GoodReads评论...
正在检索DOGObooks的评论

标签

所有的用户标签 (1)

查看最热门的标签,展示的形式是: 标签列表 | 标签云(tag cloud)

  • good  (由 1 个人)

相似资料

这资料的用户列表 (1)

确认申请

你可能已经申请过这份资料。如果还是想申请,请选确认。

链接数据


<http://www.worldcat.org/oclc/365863444>
library:oclcnum"365863444"
owl:sameAs<info:oclcnum/365863444>
rdf:typeschema:Article
schema:contributor
schema:contributor
schema:contributor
schema:contributor
schema:contributor
schema:creator
schema:datePublished"2008-12-11"
schema:description"Many pharmacological and toxicological actions of drugs in children cannot be fully predicted from adult clinical experience or from standard non-clinical toxicology studies. Numerous drugs have direct or indirect pharmacological effects on the heart and are prescribed for children of all ages. Toxicity or secondary effects may be immediate or delayed for years after drug exposure has ceased. Originally, the aim of this review was to compile information on the effect of specific drugs on the post-natal development of the cardiovascular system and to examine long-term follow-up of the use of cardio-active drugs in children. The limited database of published information caused the original question to evolve into an examination of the medical literature for three areas of information: (i) whether vulnerable developmental windows have been identified that reflect the substantial functional development that the cardiovascular system undergoes after birth; (ii) what is known about pharmacological perturbation of development; and (iii) what the likelihood is of drug exposure during childhood. We examined different scenarios for exposure including random, isolated exposure, conditions historically associated with adults, primary or secondary cardiac disease, psychiatric and neurological conditions, asthma, cancer and HIV. Except for random, isolated drug exposures, each category of possible exposure contained numerous drugs known to have either primary or secondary effects on the cardiovascular system or to influence factors associated with atherosclerosis. It is likely that a significant number of children will be prescribed drugs having either direct or indirect effects upon the immature cardiovascular system. A confounding factor is the simultaneous use of over-the-counter medications and herbal or nutraceutical preparations that a patient, parent or guardian does not mention to a prescribing physician. Metabolism is also important in assessing drug effects in children. Differences in body water : body fat ratio, age-related gastrointestinal absorption, distribution, excretion, renal function and drug metabolizing capabilities make it possible for children to have a different metabolite profile for a drug compared with adults. There is little examination of drug effects on the interdependent processes of cardiac maturation and less examination of metabolite effects. It is difficult to identify delayed toxicities in children as these adverse events may take years to manifest with many patients lost to follow-up. Clearly this is an area of study where intermediate endpoints and surrogate markers would be of great benefit. Pharmacogenomics may be useful in providing markers of increased risk or susceptibility. A perspective must be kept in balancing the possibility of a problem with the very real benefits that many children experience from the use of these pharmaceuticals."
schema:exampleOfWork<http://worldcat.org/entity/work/id/159255745>
schema:inLanguage"en"
schema:isPartOf
schema:name"Long-Term Consequences of Drugs on the Paediatric Cardiovascular System"
schema:pageStart"1083"
schema:publisher
schema:url

Content-negotiable representations

关闭窗口

请登入WorldCat 

没有张号吗?很容易就可以 建立免费的账号.