skip to content
Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom.
ClosePreview this item
Checking...

Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom.

Author: AA Syed Affiliation: School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom.JA IrvingCP RedfernAG HallNC UnwinAll authors
Edition/Format: Article Article : English
Publication:The Journal of clinical endocrinology and metabolism, 2004 Jan; 89(1): 232-5
Other Databases: WorldCatWorldCat
Summary:
Similarities between clinical states of glucocorticoid excess and obesity have raised suspicion of a link between the two conditions. An Asn363Ser (N363S) polymorphism in exon 2 of the glucocorticoid receptor has been associated with glucocorticoid sensitivity and excess adiposity in people of European origin. Compared with Europid populations, South Asians have a higher prevalence of cardiovascular risk factors,  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

&AllPage.SpinnerRetrieving;

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Document Type: Article
All Authors / Contributors: AA Syed Affiliation: School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom.; JA Irving; CP Redfern; AG Hall; NC Unwin; M White; RS Bhopal; KG Alberti; JU Weaver
ISSN:0021-972X
Language Note: English
Unique Identifier: 111656920
Awards:

Abstract:

Similarities between clinical states of glucocorticoid excess and obesity have raised suspicion of a link between the two conditions. An Asn363Ser (N363S) polymorphism in exon 2 of the glucocorticoid receptor has been associated with glucocorticoid sensitivity and excess adiposity in people of European origin. Compared with Europid populations, South Asians have a higher prevalence of cardiovascular risk factors, including type 2 diabetes and central obesity. The aim of this study was to determine the prevalence of the 363S allele in people of South Asian origin living in northeast England in relation to obesity and other cardiovascular risk factors. DNA from 142 males and 153 females was characterized for 363S allele status. Two N363S heterozygotes were identified; both subjects had raised body mass index and central obesity. Despite a higher prevalence of overweight (body mass index >/==" BORDER="0"> 25 kg/m(2)) people in the South Asian group compared with the Europid population in the same geographical area (66 vs. 56%, respectively), the 363S allele frequency was significantly lower in the South Asian group (0.3 vs. 3%, respectively). Therefore, the N363S polymorphism is unlikely to be an important factor in obesity and/or dysmetabolic traits in people of South Asian origin living in the United Kingdom.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/111656920> # Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom.
    a schema:CreativeWork, schema:Article ;
    library:oclcnum "111656920" ;
    rdfs:comment "949 $l Journal Article" ;
    schema:about <http://experiment.worldcat.org/entity/work/data/82551427#Place/great_britain> ; # Great Britain
    schema:about <http://experiment.worldcat.org/entity/work/data/82551427#Place/asia> ; # Asia
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/redfern_cp> ; # Redfern CP
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/alberti_kg> ; # Alberti KG
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/weaver_ju> ; # Weaver JU
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/hall_ag> ; # Hall AG
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/bhopal_rs> ; # Bhopal RS
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/white_m> ; # White M
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/irving_ja> ; # Irving JA
    schema:contributor <http://experiment.worldcat.org/entity/work/data/82551427#Person/unwin_nc> ; # Unwin NC
    schema:creator <http://experiment.worldcat.org/entity/work/data/82551427#Person/syed_aa> ; # Syed AA
    schema:description "Similarities between clinical states of glucocorticoid excess and obesity have raised suspicion of a link between the two conditions. An Asn363Ser (N363S) polymorphism in exon 2 of the glucocorticoid receptor has been associated with glucocorticoid sensitivity and excess adiposity in people of European origin. Compared with Europid populations, South Asians have a higher prevalence of cardiovascular risk factors, including type 2 diabetes and central obesity. The aim of this study was to determine the prevalence of the 363S allele in people of South Asian origin living in northeast England in relation to obesity and other cardiovascular risk factors. DNA from 142 males and 153 females was characterized for 363S allele status. Two N363S heterozygotes were identified; both subjects had raised body mass index and central obesity. Despite a higher prevalence of overweight (body mass index >/==" BORDER="0"> 25 kg/m(2)) people in the South Asian group compared with the Europid population in the same geographical area (66 vs. 56%, respectively), the 363S allele frequency was significantly lower in the South Asian group (0.3 vs. 3%, respectively). Therefore, the N363S polymorphism is unlikely to be an important factor in obesity and/or dysmetabolic traits in people of South Asian origin living in the United Kingdom." ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/82551427> ;
    schema:isPartOf <http://worldcat.org/issn/0021-972X#89_1> ;
    schema:name "Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom." ;
    schema:pageStart "232" ;
    schema:productID "111656920" ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/111656920> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/82551427#Place/great_britain> # Great Britain
    a schema:Place ;
    schema:name "Great Britain" ;
    .

<http://worldcat.org/issn/0021-972X>
    a schema:Periodical ;
    rdfs:label "The Journal of clinical endocrinology and metabolism" ;
    schema:issn "0021-972X" ;
    .

<http://www.worldcat.org/title/-/oclc/111656920>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/111656920> ; # Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom.
    schema:dateModified "2016-07-25" ;
    void:inDataset <http://purl.oclc.org/dataset/medline> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.