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Malaria

Author: Juliana Carvalho Tavares
Publisher: San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.
Series: Colloquium digital library of life sciences.; Colloquium series on integrated systems physiology, # 45.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This ebook describes the pathogenesis of malaria and the major consequences of the parasitism to the vertebrate host. Malaria is one of the oldest infectious diseases of mankind, which still exerts a high burden on human health and society. It is caused by parasites of the genus Plasmodium, and transmitted by Anopheline mosquitoes. Despite several decades of intensive control efforts, malaria remains widely  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Juliana Carvalho Tavares
ISBN: 9781615046379 1615046372 1615046364 9781615046362
OCLC Number: 860982116
Notes: Part of: Colloquium digital library of life sciences.
Title from PDF title page (viewed on October 18, 2013).
Series from website.
Description: 1 online resource (1 PDF (ix, 177 pages)) : illustrations.
Contents: 1. Malaria pathogenesis / Fernando Fonseca de Almeida e Val, Wuelton Marcelo Monteiro, and Marcus Vinícius Guimarães de Lacerda --
1.1 Parasite biomass --
1.2 Inflammatory response --
1.3 Infected erythrocytes: deformability/rosetting --
1.4 Endothelial alterations --
1.5 Cytoadherence/sequestration --
1.6 Clinical complications --
1.6.1 Anemia --
1.6.2 Thrombocytopenia/coagulation disorders --
1.6.3 Jaundice --
1.6.4 Metabolic complications --
1.6.5 Pregnancy-related malaria --
1.6.6 Respiratory distress and lung injury --
1.6.7 Neurological syndrome and coma --
1.6.8 Acute renal failure --
1.6.9 Algid malaria/shock --
1.6.10 Atypical manifestations --
1.7 Comorbidities. 2. Possible mechanisms to explain plasmodium immunopathogenesis: the role of parasite and human host genetic diversity / Ricardo Luiz Dantas Machado --
2.1 Plasmodium falciparum related pathogenesis --
2.2 Plasmodium vivax related pathogenesis --
2.3 Cytoadherence and virulence of plasmodium knowlesi malaria --
2.4 Concluding remarks. 3. Malarial anemia: a multifactorial hematological outcome / Luiza Carvalho Mourão, Thiago Castro Gomes, and Erika M. Braga --
3.1 Introduction --
3.2 Anemia and parasite biomass are not associated --
3.3 Rosette formation and cytoadherence --
3.4 The participation of inflammatory cytokines --
3.5 The involvement of nitric oxide (NO) in anemia --
3.6 Phagocytosis of malaria-infected and non-infected RBCs --
3.7 Complement proteins and anemia --
3.8 The possible role of autoantibodies --
3.9 Concluding remarks. 4. Immune response to malaria blood stage / Onesia Cristina Oliveira Lima and Juliana Carvalho Tavares --
4.1 Introduction --
4.2 Mouse models for malaria research --
4.3 Life cycle of the malaria parasite --
4.4 Dendritic cells --
4.5 CD4 T Cells --
4.6 NK (natural killer) cells --
4.7 CD4+CD25+Foxp3+ regulatory T Cells --
4.8 yo T-cel --
4.9 Monocite/macrophages --
4.10 B cells --
4.11 Concluding remarks. 5. Human cerebral malaria and experimental models / Leonardo J.M. Carvalho and Yuri C. Martins --
5.1 Introduction --
5.2 Cerebral malaria: epidemiology, clinical presentation, diagnosis and management --
5.3 Pathogenesis --
5.4 Adjunctive therapies --
5.5 Animal models of CM --
5.6 Conclusion. 6. Blood-brain barrier disruption in cerebral malaria / Marcelo Limborço Filho and Juliana Carvalho Tavares --
6.1 Introduction --
6.1.1 Healthy blood-brain barrier: structure and function --
6.2 How is it possible to study BBB permeability? --
6.3 Rupture of the BBB in CM --
6.4 What mechanisms might underlie BBB dysfunction in cerebral malaria? --
6.5 PRBC sequestration and interaction with BBB --
6.6 Consequences of PRBC adhesion on endothelial cell (BBB) --
6.7 Apoptosis of endothelial cell blood brain barrier --
6.8 Inflammatory mediators --
6.9 Leukocyte and platelet recruitment --
6.10 How can platelets modulate EC-PRBC interaction and subsequent sequelae? --
6.11 Consequences of BBB rupture on astrocytes and microglia --
6.12 Concluding remarks. 7. Persistent cognitive and memory impairment after cerebral malaria: molecular mechanisms and pre-clinical models of adjuvant therapy / Patricia Alves Reis, Tatiana Maron-Gutierrez, Hugo Caire de Castro Faria Neto, and Guy Zimmerman --
7.1 Introduction --
7.2 Cognitive impairment in cerebral malaria, what do we know so far? --
7.3 Neuroinflammation and cognitive impairment in cerebral malaria --
7.4 Mechanisms of memory impairment after cerebral malaria --
7.5 Therapeutic approaches to tissue damage associated to cerebral malaria --
7.6 Concluding remarks --
Bibliography.
Series Title: Colloquium digital library of life sciences.; Colloquium series on integrated systems physiology, # 45.
Responsibility: Juliana Carvalho Tavares.

Abstract:

This ebook describes the pathogenesis of malaria and the major consequences of the parasitism to the vertebrate host. Malaria is one of the oldest infectious diseases of mankind, which still exerts a high burden on human health and society. It is caused by parasites of the genus Plasmodium, and transmitted by Anopheline mosquitoes. Despite several decades of intensive control efforts, malaria remains widely distributed with an estimated 3.3 billion of the world's population at risk of infection. The malaria life cycle is extremely complex and the blood stage parasites are responsible for all the symptoms and pathology of malaria. Because of this strict association between the parasites and red cells, there are numerous consequences to the host's blood extending far beyond the direct effect of parasitized RBCs.

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