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Mammalian alkaline phosphatases : from biology to applications in medicine and biotechnology.

Author: José Luis Millán; John Wiley & Sons.
Publisher: Weinheim : Wiley-VCH, ©2006.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: The structure, regulation and expression of the AP genes; The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes; The phenotypic abnormalities of the different AP knockout mice; Our current  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Millán, José Luis.
Mammalian alkaline phosphatases.
Weinheim : Wiley-VCH, ©2006
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: José Luis Millán; John Wiley & Sons.
ISBN: 3527310797 9783527310791 3527608060 9783527608065 9783527607471 3527607471
OCLC Number: 85821108
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xv, 322 pages)
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Preface --
Abbreviations --
Glossary --
Introduction --
pt. I. Gene and protein structure ; 1. Gene structures ; 2. Developmental expression ; 3. Gene regulation ; 4. Protein structure and functional domains ; 5. Enzymatic properties ; 6. Epitope maps --
pt. II. In vivo functions ; 7. The in vivo role of TNAP ; 8. Knockout mouse models --
pt. III. AP expression in health and disease ; 9. APs as physiological and disease markers ; 10. Neoplastic expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP isozymes --
pt. IV. Uses of APs in industry and biotechnology ; 11. Applications of recombinan APs ; 12. Use of APs in prodrug converting strategies ; 13. APs as therapeutic agents ; 14. APs in the food industry ; 15. Veterinary uses of AP determinations ; 16. Methodologies.

Abstract:

A summary of the dramatic increase in our knowledge of this field made over the last 20 years. The book also describes the possible use of APs as targets for treatment and the many uses of these  Read more...

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