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Mammalian chromosome engineering : methods and protocols

Author: Gyula Hadlaczky
Publisher: [New York] : Humana Press, ©2011.
Series: Methods in molecular biology (Clifton, N.J.), v. 738.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The rapid progression of genetics and molecular biology has turned chromosomal engineering from science fiction to reality, with the successful production of transgenic animals with engineered chromosomes and chromosomes developed for pharmaceutical protein production which are now ready for the medical industry. Mammalian Chromosome Engineering: Methods and Protocols provides the reader with up-to date information  Read more...
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Genre/Form: Laboratory Manuals
Electronic books
Additional Physical Format: Print version:
Mammalian chromosome engineering.
New York : Humana, ©2011
(DLC) 2011923965
(OCoLC)706626327
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gyula Hadlaczky
ISBN: 9781617790997 1617790990
OCLC Number: 719367742
Description: 1 online resource (ix, 257 pages).
Contents: Developing extrachromosomal gene expression vector technologies: An overview --
High capacity extrachromosomal gene expression vectors --
Naturally occurring minichromosome platforms in chromosome engineering: An overview --
Chromosome transfer via cell fusion --
Insertional engineering of chromosomes with Sleeping Beauty transposition: An overview --
Rodent transgenesis mediated by a novel hyperactive Sleeping Beauty transposon system --
Construction and use of a bottom-up HAC vector for transgene expression --
De novo generation of satellite DNA-based artificial chromosomes by induced large-scale amplification --
Downstream bioengineering of ACE chromosomes for incorporation of site-specific recombination cassettes --
Chromosome engineering with [lambda]-integrase mediated recombination system: The ACE system --
Dendrimer mediated transfer of engineered chromosomes --
Engineered chromosomes in transgenics --
Transfer of stem cells carrying engineered chromosomes with XY clone laser system --
Mammalian artificial chromosomes and clinical applications for genetic modification of stem cells: An overview --
Engineered mammalian chromosomes in cellular protein production: Future prospects.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 738.
Responsibility: edited by Gyula Hadlaczky.
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Abstract:

Provides the reader with information on the field of Mammalian Chromosome Engineering, and takes the reader into the realm of chromosomal engineering from the basic principles to the practical  Read more...

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