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Management of castration resistant prostate cancer

Author: Fred Saad; Mario A Eisenberger
Publisher: New York, NY : Humana Press, 2014.
Series: Current clinical urology
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Fred Saad; Mario A Eisenberger
ISBN: 9781493911769 1493911767 1493911759 9781493911752
OCLC Number: 889945340
Notes: Includes index.
Description: 1 online resource (xvi, 337 pages) : illustrations (some color).
Contents: Introduction --
Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities --
Evolution of Clinical States and the Castration Resistant Clinical Paradigm --
Molecular Mechanisms of Prostate Cancer Progression after Castration --
New Imaging Modalities --
Androgen Receptor Biology in Castration Resistant Prostate Cancer --
The Androgen Receptor as a Therapeutic Target for Castration-Resistant Prostate Cancer --
Approaches Targeting Androgen Synthesis (CYP 17 inhibitors) --
Cytotoxic Chemotherapy (Taxanes and Taxane Combinations) --
The Emerging Role of Immunotherapy in Castrate Resistant Prostate Cancer --
Bone Targeted Therapy: Rationale and Current Status --
Radium-223 and Other Radiopharmaceuticals in Prostate Cancer --
Introduction --
Phase I/II targeted treatments --
Defining Clinical Endpoints in Castration-resistant Prostate Cancer --
Angiogenesis Inhibition in Castration Resistant Prostate Cancer --
Co-targeting Adaptive Survival Pathways --
Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer --
PARP Inhibitors --
Targeting C-Met/VEGF in Castration Resistant Prostate Cancer --
Epigenetics in Castration Resistant Prostate Cancer --
Undifferentiated Prostate Cancer and the Neuroendocrine Phenotype --
Strategies Addressing Quality of Life: Patient Reported Outcome and Symptoms Management --
Evidence-Based Therapeutic Approaches for mCRPC patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development.
Series Title: Current clinical urology
Responsibility: Fred Saad, Mario A. Eisenberger, editors.

Abstract:

This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC.  Read more...

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From the book reviews:"This volume in the Current Clinical Urology series focuses on the management of castration resistant prostate cancer (CRPC), providing an important reference for medical Read more...

 
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