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Management of Chemical and Biological Samples for Screening Applications.

Author: Mark Wigglesworth; Terry Wood
Publisher: Hoboken : John Wiley & Sons, 2012.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire field of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Wigglesworth, Mark.
Management of Chemical and Biological Samples for Screening Applications.
Hoboken : John Wiley & Sons, ©2012
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mark Wigglesworth; Terry Wood
ISBN: 9783527645275 3527645276
OCLC Number: 773567113
Notes: 6.4 A Lean Laboratory Toolbox.
Description: 1 online resource (434 pages)
Contents: Management of Chemical and Biological Samples for Screening Applications; Contents; Preface; List of Contributors; 1 Introduction to Sample Management; References; 2 Generating a High-Quality Compound Collection; 2.1 Defining Current Screening Collections; 2.2 Design Criteria for Enriching a Compound Collection with Drug-Like Compounds; 2.2.1 Physicochemical Tailoring of a Compound Collection; 2.2.2 Lipophilicity Design Considerations; 2.2.3 Other Physicochemical Roadblocks; 2.2.4 Assessing Risk --
from Rule of 5 to Rule of 3/75; 2.2.5 Tools Enabling Desk Top In Silico Design. 2.3 Concluding RemarksReferences; 3 Assessing Compound Quality; 3.1 Introduction; 3.2 Process Quality and Analytical Quality in Compound Management; 3.2.1 Process Quality (QA); 3.2.2 Analytical Quality (Sample QC); 3.3 Identity; 3.4 Purity/Stability; 3.4.1 Measuring Purity; 3.4.2 Determining the Most Appropriate Purity Cut-Off for Solutions; 3.4.3 Stability of Solutions; 3.5 Concentration/Solubility; 3.6 Conclusions; Acknowledgments; References; Further Reading; 4 Delivering and Maintaining Quality within Compound Management; 4.1 Introduction. 4.2 What is Quality from a Compound Management Perspective?4.3 Storage and Delivery of Samples in Solution; 4.4 Intercepting Low Purity; 4.5 Storage and Delivery of Solids; 4.6 Automation Quality Control and Reliability; 4.7 High-Quality Data Management; 4.8 Conclusion; Acknowledgments; References; 5 Obtaining and Maintaining High-Quality Tissue Samples: Scientific and Technical Considerations to Promote Evidence-Based Biobanking Practice (EBBP); 5.1 Introduction; 5.1.1 Current Issues and Impediments to Benchmark Level Biospecimen Research. 5.1.2 The Role of the Research Protocol in Preserving Biospecimen Quality5.1.3 Rationale for Best Practice Integration into Sample Management Procedures and Protocols; 5.2 The Path toward Integration of Evidence-based Biobanking Practice; 5.2.1 Conceptual Foundations of Evidence-based Biobanking Practice; 5.2.2 The Pre- and Post-Acquisition Analytic Variable Relationship to EBBP; 5.2.3 The Biospecimen Lifecycle Concept: a Framework to Aid EBBP Protocol Design; 5.3 Integrating Evidence-based Biobanking Practice into Sample Protocols; 5.3.1 Protocol Planning for EBBP-based Sample Management. 5.3.2 Crucial Scientific and Technical Considerations for EBBP Protocol Design5.3.3 Utilizing Publication Reporting Guidelines to Guide EBBP Protocol Design; 5.4 Final Thoughts and Recommendations; 5.4.1 Proposed Staging System to Qualify EBBP Related Data; 5.4.2 Revisiting Crucial Considerations Related to Implementation of EBBP; 5.4.3 Strategies to Optimize Real-Time Implementation of EBBP; References; 6 Thinking Lean in Compound Management Laboratories; 6.1 The Emergence of 'Lean Thinking'; 6.2 The Application of 'Lean Thinking'; 6.3 Lean Thinking in Drug Discovery.

Abstract:

For the first time the working knowledge of large screening centers in the pharmaceutical and biotechnological field is tied together to produce an integrated view of sample management that spans the  Read more...

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"In the same vein, the chapters on new and enablingtechnologies, as well as how best to approach the options foroutsourcing samples serve to provide a complete overview of allaspects of this Read more...

 
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