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Manufacturing of Gene Therapeutics : Methods, Processing, Regulation, and Validation

Author: G Subramanian
Publisher: Boston, MA : Springer US, 2002.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Advances in molecular biology and recombinant DNA technology have accelerated progress in many fields of life science research, including gene therapy. A large number of genetic engineering approaches and methods are readily available for gene cloning and therapeutic vector construction. Significant progress is being made in genomic, DNA sequencing, gene expression, gene delivery and cloning. Thus gene therapy has  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: G Subramanian
ISBN: 9781461513537 1461513537
OCLC Number: 852791655
Description: 1 online resource (xvii, 345 pages)
Contents: Somatic Gene Therapy, Paradigm Shift or Pandora's Box: A Perspective on Gene Therapy --
Gene Therapy for Cancer: Deceiving the Malignant Cell --
Gene Self-Assembly (GENSA): Facilitating the Construction of Genes and Vectors --
Gene Expression --
Tumour Genotype and Response to Cytotoxic Gene Therapy --
Protein Binding Matrices: Tools for Phenol-free Cloning and Vector Assembling --
Gene Transfer into Eukaryotic Cells --
Plasmid DNA Manufacturing --
Quality Assurance and Quality Control for Viral Therapeutics --
Analytical Assays to Characterise Adenoviral Vectors and Their Applications --
Validation of Gene Therapy Manufacturing Processes: A Case Study for Adenovirus Vectors --
Gene Delivery --
Regulatory Issues in Gene Therapy. Good Science --
Good Sense --
Regulatory Aspects in Gene Therapy: Special Highlights on European Regulation --
Regulatory Issues for Process Development and Manufacture of Plasmids Under Contract --
Risk Assessment in Gene Therapy.
Responsibility: edited by G. Subramanian.

Abstract:

This book provides an overview of the current advances in the field of gene therapy and the methods that are being successfully applied in the manufacture of gene therapeutic products, and  Read more...

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