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Mass spectrometry in drug metabolism and pharmacokinetics

Author: Ragu Ramanathan; Wiley InterScience (Online service)
Publisher: Hoboken, N.J. : Wiley, ©2009.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Mass spectrometry in drug metabolism and pharmacokinetics.
Hoboken, N.J. : Wiley, ©2009
(DLC) 2008021424
(OCoLC)174129887
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ragu Ramanathan; Wiley InterScience (Online service)
ISBN: 9780470409817 0470409819 9780470409800 0470409800 1282687549 9781282687547 9781118211571 111821157X
OCLC Number: 299046780
Description: 1 online resource (xii, 389 pages) : illustrations
Contents: Evolving role of mass spectrometry in drug discovery and development / Dil M. Ramanathan and Richard M. LeLacheur --
Quantitative bioanalysis in drug discovery and development : principles and applications / Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen --
Quadrupole, triple-quadrupole, and hybrid linear ion trap mass spectrometers in metabolite analysis / Elliott B. Jones --
Applications of quadrupole time-of-flight mass spectrometry in reactive metabolite screening / Jose M. Castro-Perez --
Changing role of FTMS in drug metabolism / Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders --
High-resolution LC-MS based mass defect filter approach : basic concept and application in metabolite detection / Haiying Zhang [and others]. Applications of high-sensitivity mass spectrometry and radioactivity detection techniques in drug metabolism studies / Wing W. Lam [and others] --
Online electrochemical-LC-MS techniques for profiling and characterizing metabolites and degradants / Paul H. Gamache [and others] --
LC-MS methods with hydrogen/deuterium exchange for identification of hydroxylamine, n-oxide, and hydroxylated analogs of desloratadine / Natalia A. Penner [and others] --
Turbulent-flow LC-MS : applications for accelerating pharmacokinetic profiling and metabolite identification / Joseph L. Herman and Joseph M. Di Bussolo --
Desorption ionization techniques for quantitative analysis of drug molecules / Jason S. Gobey, John Janiszewski, and Mark J. Cole --
MALDI imaging mass spectrometry for direct tissue analysis of pharmaceuticals / Yunsheng Hsieh and Walter A. Korfmacher.
Responsibility: edited by Ragu Ramanathan.

Abstract:

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies.  Read more...

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"All in all, the book delivers on its promises to introduce and review the current art of mass spectrometry for the related disciplines of drug metabolism and pharmacokinetics. I highly recommend Read more...

 
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