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Mast cells and tumours : from biology to clinic

Author: Domenico Ribatti; Enrico Crivellato
Publisher: Dordrecht ; New York : Springer, ©2011.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Ribatti, Domenico.
Mast cells and tumours.
Dordrecht : Springer, 2011
(DLC) 2011927938
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Domenico Ribatti; Enrico Crivellato
ISBN: 9789400714694 9400714696 9400714688 9789400714687
OCLC Number: 745003836
Description: 1 online resource (viii, 142 pages) : illustrations
Contents: Introduction --
1. The mast cell --
1.1. A historical overview --
1.2. Biology of mast cells --
2. Mast cell mediators --
2.1. Granule composition --
2.2. Histamine and serotonin --
2.3. Proteases --
2.4. Lipid mediators --
2.5. Cytokines and growth factors --
2.6. Chemokines --
3. The tumour cell --
3.1. Biology of tumour cell --
3.2. The importance of microenvironment in tumor metastasis --
3.3. The "seed and soil" theory --
4. Tumour angiogenesis --
4.1. The angiogenic switch --
4.2. Phenotypic and genotypic characteristics of tumor vessels and genetic evidence that tumours are angiogenesis-dependent --
4.3. What is the evidence that genetic instability promotes the angiogenic switch? --
4.4. Hypoxic regulation of tumour angiogenesis --
4.5. The role of pericytes in tumour angiogenesis --
4.6. The role of inflammatory cells in tumour angiogenesis --
4.7. Participation of hematopoietic cells and endothelial precursor cells to tumour angiogenesis --
4.8. Alternative mechanisms of tumour angiogenesis --
4.9. Vascular cooption --
4.10. The prognostic significance of tumour angiogenesis --
4.11. Angiogenesis is not necessarily involved in tumour progression --
5. Mast cells and tumours --
5.1. Mast cells and tumour growth in humans: pro and contra --
6. Mast cells and tumour angiogenesis --
6.1. Mast cell-induced angiogenesis studied by means of in vitro and in vivo assays --
6.2. Mast cell-induced angiogenesis studied by means of experimental carcinogenesis --
6.3. Angiogenic factors stored in mast cells --
6.4. Mast cells and angiogenesis in human solid tumours --
6.5. Mast cells and angiogenesis in human hematological tumours --
7. Mast cells and tumour lymphangiogenesis --
8. Drug affecting mast cells --
Concluding remarks and perspectives --
References.
Responsibility: Domenico Ribatti, Enrico Crivellato.

Abstract:

This book describes the general biology of mast cells, their development, anatomical distribution, phenotype and secretory products, as well as the biology of tumour cells, the tumour  Read more...

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