skip to content
Matrix metalloproteinase inhibitors in cancer therapy Preview this item
ClosePreview this item
Checking...

Matrix metalloproteinase inhibitors in cancer therapy

Author: Neil J Clendeninn; Krzysztof Appelt
Publisher: Totowa, N.J. : Humana Press, ©2000.
Series: Cancer drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The association of matrix metalloproteinases (MMPs)-enzymes that disrupt the body's normal repair functions-with several diseases, including growing and invasive tumors, holds the tantalizing promise that their inhibiton might have therapeutic value. In Matrix Metalloproteinase Inhibitors in Cancer Therapy, cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Matrix metalloproteinase inhibitors in cancer therapy.
Totowa, N.J. : Humana Press, ©2000
(DLC) 99089543
(OCoLC)43095606
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Neil J Clendeninn; Krzysztof Appelt
ISBN: 9781592590117 159259011X
OCLC Number: 169919087
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xi, 262 pages) : illustrations (some color).
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Biology and Regulation of the Matrix Metalloproteinases, Mark D. Sternlicht, Lisa M. Coussens, Thiennu H. Vu, and Zena Werb. Substrate Specificity of MMPs, Hideaki Nagase. The Tissue Inhibitors of Metalloproteinases (TIMPs): Biology and Regulation, Dylan R. Edwards. Matrix Metalloproteinases in Cancer, Barbara Fingleton and Lynn M. Matrisian. Hydroxamic Acid Matrix Metalloproteinase Inhibitors, Peter D. Brown, Alan H. Davidson, Alan H. Drummond, Andrew Gearing, and Mark Whittaker. Prinomastat: A Potent and Selective Matrix Metalloproteinase Inhibitor-Preclinical and Clinical Development for Oncology, David R. Shalinsky, Bhasker Shetty, Yazdi Pithavala, Steve Bender, Anthony Neri, Stephanie Webber, Krzysztof Appelt, and Mary Collier. A Potent Nonpeptidic Matrix Metalloproteinase Inhibitor: Discovery of BAY 12-9566, George Clemens, Barbara Hibner, Rachel Humphrey, Harold Kluender, and Scott Wilhelm. D1927 and D2163: Novel Mercaptoamide Inhibitors of Matrix Metalloproteinases, A.D. Baxter, J.B. Bird, R. Bannister, R. Bhogal, D.T. Manallack, R.W. Watson, D.A. Owen, J. Montana, J. Henshilwood, and Robert C. Jackson. Research on MMP Inhibitors with Unusual Scaffolds, Frank Grams, Hans Brandstetter, Richard A. Engh, Dagmar Glitz, Hans-Willi Krell, Valeria Livi, Ernesto Menta, Luis Moroder, J. Constanze D. Muller, Erich Graf v. Roedern, and Gerd Zimmerman. Matrix Metalloproteinase Inhibitors: Therapeutic Applications Outside of Oncology, Michael R. Niesman. Index.
Series Title: Cancer drug discovery and development.
Responsibility: edited by Neil J. Clendeninn and Krzysztof Appelt.

Abstract:

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies.  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/169919087> # Matrix metalloproteinase inhibitors in cancer therapy
    a schema:MediaObject, schema:Book, schema:CreativeWork ;
    library:oclcnum "169919087" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nju> ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/766948132#Place/totowa_n_j> ; # Totowa, N.J.
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/neoplasms_drug_therapy> ; # Neoplasms--drug therapy
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/extracellular_matrix_enzymology> ; # Extracellular Matrix--enzymology
    schema:about <http://id.worldcat.org/fast/810595> ; # Antineoplastic agents
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/extracellular_matrix_proteins_inhibitors_therapeutic_use> ; # Extracellular matrix proteins--Inhibitors--Therapeutic use
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/health_&_fitness_diseases_cancer> ; # HEALTH & FITNESS--Diseases--Cancer
    schema:about <http://dewey.info/class/616.994061/e22/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/metalloproteinases_inhibitors_therapeutic_use> ; # Metalloproteinases--Inhibitors--Therapeutic use
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/cancer_chemotherapy> ; # Cancer--Chemotherapy
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/extracellular_matrix_proteins> ; # Extracellular matrix proteins
    schema:about <http://id.loc.gov/authorities/subjects/sh85019497> ; # Cancer--Chemotherapy
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/medical_oncology> ; # MEDICAL--Oncology
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/metalloendopeptidases_metabolism> ; # Metalloendopeptidases--metabolism
    schema:about <http://id.worldcat.org/fast/845327> ; # Cancer--Chemotherapy
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/metalloendopeptidases_antagonists_&_inhibitors> ; # Metalloendopeptidases--antagonists & inhibitors
    schema:about <http://id.worldcat.org/fast/918997> ; # Extracellular matrix proteins
    schema:about <http://experiment.worldcat.org/entity/work/data/766948132#Topic/antineoplastic_agents> ; # Antineoplastic agents
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/1239485> ; # Neil J. Clendeninn
    schema:contributor <http://viaf.org/viaf/3700730> ; # Krzysztof Appelt
    schema:copyrightYear "2000" ;
    schema:datePublished "2000" ;
    schema:description "The association of matrix metalloproteinases (MMPs)-enzymes that disrupt the body's normal repair functions-with several diseases, including growing and invasive tumors, holds the tantalizing promise that their inhibiton might have therapeutic value. In Matrix Metalloproteinase Inhibitors in Cancer Therapy, cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their company's research effort on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, and efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/766948132> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/766948132#Series/cancer_drug_discovery_and_development> ; # Cancer drug discovery and development.
    schema:isSimilarTo <http://www.worldcat.org/oclc/43095606> ;
    schema:name "Matrix metalloproteinase inhibitors in cancer therapy"@en ;
    schema:productID "169919087" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/169919087#PublicationEvent/totowa_n_j_humana_press_2000> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/766948132#Agent/humana_press> ; # Humana Press
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=201243> ;
    schema:url <http://www.myilibrary.com?id=82161> ;
    schema:url <http://site.ebrary.com/id/10181284> ;
    schema:url <https://link.springer.com/openurl?genre=book&isbn=978-0-89603-668-0> ;
    schema:url <http://dx.doi.org/10.1007/978-1-59259-011-7> ;
    schema:url <http://catalog.hathitrust.org/api/volumes/oclc/43095606.html> ;
    schema:url <http://link.springer.com/10.1007/978-1-59259-011-7> ;
    schema:url <http://books.google.com/books?id=V4lrAAAAMAAJ> ;
    schema:workExample <http://worldcat.org/isbn/9781592590117> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/169919087> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/766948132#Agent/humana_press> # Humana Press
    a bgn:Agent ;
    schema:name "Humana Press" ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Series/cancer_drug_discovery_and_development> # Cancer drug discovery and development.
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/169919087> ; # Matrix metalloproteinase inhibitors in cancer therapy
    schema:name "Cancer drug discovery and development." ;
    schema:name "Cancer drug discovery and development" ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/antineoplastic_agents> # Antineoplastic agents
    a schema:Intangible ;
    schema:name "Antineoplastic agents"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/cancer_chemotherapy> # Cancer--Chemotherapy
    a schema:Intangible ;
    schema:name "Cancer--Chemotherapy"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/extracellular_matrix_enzymology> # Extracellular Matrix--enzymology
    a schema:Intangible ;
    schema:name "Extracellular Matrix--enzymology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/extracellular_matrix_proteins> # Extracellular matrix proteins
    a schema:Intangible ;
    schema:name "Extracellular matrix proteins"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/extracellular_matrix_proteins_inhibitors_therapeutic_use> # Extracellular matrix proteins--Inhibitors--Therapeutic use
    a schema:Intangible ;
    schema:hasPart <http://id.loc.gov/authorities/subjects/sh93000875> ;
    schema:name "Extracellular matrix proteins--Inhibitors--Therapeutic use"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/health_&_fitness_diseases_cancer> # HEALTH & FITNESS--Diseases--Cancer
    a schema:Intangible ;
    schema:name "HEALTH & FITNESS--Diseases--Cancer"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/medical_oncology> # MEDICAL--Oncology
    a schema:Intangible ;
    schema:name "MEDICAL--Oncology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/metalloendopeptidases_antagonists_&_inhibitors> # Metalloendopeptidases--antagonists & inhibitors
    a schema:Intangible ;
    schema:name "Metalloendopeptidases--antagonists & inhibitors"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/metalloendopeptidases_metabolism> # Metalloendopeptidases--metabolism
    a schema:Intangible ;
    schema:name "Metalloendopeptidases--metabolism"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/metalloproteinases_inhibitors_therapeutic_use> # Metalloproteinases--Inhibitors--Therapeutic use
    a schema:Intangible ;
    schema:hasPart <http://id.loc.gov/authorities/subjects/sh94005070> ;
    schema:name "Metalloproteinases--Inhibitors--Therapeutic use"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/766948132#Topic/neoplasms_drug_therapy> # Neoplasms--drug therapy
    a schema:Intangible ;
    schema:name "Neoplasms--drug therapy"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85019497> # Cancer--Chemotherapy
    a schema:Intangible ;
    schema:name "Cancer--Chemotherapy"@en ;
    .

<http://id.worldcat.org/fast/810595> # Antineoplastic agents
    a schema:Intangible ;
    schema:name "Antineoplastic agents"@en ;
    .

<http://id.worldcat.org/fast/845327> # Cancer--Chemotherapy
    a schema:Intangible ;
    schema:hasPart <http://id.loc.gov/authorities/subjects/sh85019497> ; # Cancer--Chemotherapy
    schema:name "Cancer--Chemotherapy"@en ;
    .

<http://id.worldcat.org/fast/918997> # Extracellular matrix proteins
    a schema:Intangible ;
    schema:name "Extracellular matrix proteins"@en ;
    .

<http://viaf.org/viaf/1239485> # Neil J. Clendeninn
    a schema:Person ;
    schema:familyName "Clendeninn" ;
    schema:givenName "Neil J." ;
    schema:name "Neil J. Clendeninn" ;
    .

<http://viaf.org/viaf/3700730> # Krzysztof Appelt
    a schema:Person ;
    schema:familyName "Appelt" ;
    schema:givenName "Krzysztof" ;
    schema:name "Krzysztof Appelt" ;
    .

<http://worldcat.org/isbn/9781592590117>
    a schema:ProductModel ;
    schema:isbn "159259011X" ;
    schema:isbn "9781592590117" ;
    .

<http://www.worldcat.org/oclc/43095606>
    a schema:CreativeWork ;
    rdfs:label "Matrix metalloproteinase inhibitors in cancer therapy." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/169919087> ; # Matrix metalloproteinase inhibitors in cancer therapy
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.