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Mechanisms of lymphocyte activation and immune regulation VIII : autoimmunity 2000 and beyond

Author: Sudhir Gupta
Publisher: New York : Kluwer Academic/Plenum, ©2001.
Series: Advances in experimental medicine and biology, v. 490.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
Advances in biochemistry, cell biology, genome-wide mutagenesis -- coupled with molecular technology, including gene microarray and transgenic and knock-out animals -- have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Sudhir Gupta
ISBN: 0306465701 9780306465703
OCLC Number: 45799987
Description: viii, 136 pages : illustrations ; 26 cm.
Contents: 1. Basic mechanisms --
Delineation of the pathogenesis of systemic lupus erythematosus by using murine models --
Factors contributing to autoimmune disease --
Control of autoimmunity by regulatory T cells --
Autoimmunity, self-tolerance, and immune homeostasis: from whole animal phenotypes to molecular pathways --
Peripheral tolerance and organ specific autoimmunity --
Autoimmune lymphoproliferative syndrome: types I, II, and beyond --
2. Pathogenesis --
The role of MHC class II molecules in the pathogenesis and prevention of type I diabetes --
Control of autoreactive T cell activation by immuoregulatory T cells --
Immune tolerance and the nervous system --
Functional role of epitope spreading in the chronic pathogenesis of autoimmune and virus-induced demyelinating diseases --
3. Therapy --
Multiple sclerosis and gene expesssion profiling --
Treatment of autoimmuity by inhibition of T cell costimulation --
Cytokine blockade in rheumatoid arthritis.
Series Title: Advances in experimental medicine and biology, v. 490.
Responsibility: edited by Sudhir Gupta.
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Abstract:

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in  Read more...

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