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Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets

Author: Urs A Boelsterli
Publisher: London ; New York : Taylor & Francis, 2003.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Boelsterli, Urs A., 1948-
Mechanistic toxicology.
London ; New York : Taylor & Francis, 2003
(DLC) 2002072726
(OCoLC)50002578
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Urs A Boelsterli
ISBN: 0203361768 9780203361764
OCLC Number: 53003932
Description: 1 online resource (xxiv, 314 pages) : illustrations
Contents: Introduction. Mechanism of Organ-Selective Toxicity. Cellular Transport and Selective Accumulation of Toxic Compounds. Bioactivation of Xenobiotics to Reactive Metabolites. Oxidative Stress: Cell Injury, Signaling, and Gene Regulation. Disruption of Calcium Homeostasis. Apoptosis and Necrosis. Perturbation of Cell Proliferation and Tissue Repair. Covalent Interactions of Reactive Metabolites with Cellular Macromolecules. Immune Mechanisms. Specific Inactivation of Enzymes. Receptor-Mediated Toxicity. Binding of Xenobiotics to Hormone-Binding Proteins. Interaction of Xenobiotics with Ion Transporters. Disruption of Cellular Energy Production and Mitochondrial Toxicity. Xenobiotic-Induced Alterations in Gene Regulation.
Responsibility: Urs A. Boelsterli.
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Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important Read more...

 
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