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Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets

Author: Urs A Boelsterli
Publisher: Boca Raton : CRC Press, ©2007.
Edition/Format:   Print book : English : 2nd edView all editions and formats
Database:WorldCat
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Mechanistic Toxicology

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Urs A Boelsterli
ISBN: 9780849372728 0849372720
OCLC Number: 74459862
Description: 399 pages : illustrations ; 25 cm
Contents: Introduction --
Types of toxic responses --
Organ-selective toxicity --
Cellular transport and selective accumulation of potentially toxic xenobiotics --
Bioactivation of xenobiotics to reactive metabolites --
Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation --
Disruption of cellular calcium homeostasis --
Mechanisms of necrotic and apoptotic cell death --
Impairment of cell proliferation and tissue repair --
Covalent binding of reactive metabolites to cellular macromolecules --
Immune mechanisms --
Cytokine-mediated toxicity --
Specific inactivation of enzymes and other proteins --
Interactions of xenobiotics with ion transporters --
Nuclear receptor-mediated toxicity --
Activation or disruption of cellular signal transduction by xenobiotics --
Disruption of mitochondrial function and mitochondria-mediated toxicity --
Novel mechanisms derived from systems toxicology.
Responsibility: Urs A. Boelsterli.
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'Students taking formal training in toxicology would definitely benefit from adding this book to their collection, since it covers many recent advances in the field.' - British Toxicology Society Read more...

 
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