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Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets

Autor: Urs A Boelsterli
Editorial: Boca Raton : CRC Press, ©2007.
Edición/Formato:   Print book : Inglés (eng) : 2nd edVer todas las ediciones y todos los formatos
Base de datos:WorldCat
Resumen:

Mechanistic Toxicology

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Tipo de material: Recurso en Internet
Tipo de documento: Libro/Texto, Recurso en Internet
Todos autores / colaboradores: Urs A Boelsterli
ISBN: 9780849372728 0849372720
Número OCLC: 74459862
Descripción: 399 pages : illustrations ; 25 cm
Contenido: Introduction --
Types of toxic responses --
Organ-selective toxicity --
Cellular transport and selective accumulation of potentially toxic xenobiotics --
Bioactivation of xenobiotics to reactive metabolites --
Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation --
Disruption of cellular calcium homeostasis --
Mechanisms of necrotic and apoptotic cell death --
Impairment of cell proliferation and tissue repair --
Covalent binding of reactive metabolites to cellular macromolecules --
Immune mechanisms --
Cytokine-mediated toxicity --
Specific inactivation of enzymes and other proteins --
Interactions of xenobiotics with ion transporters --
Nuclear receptor-mediated toxicity --
Activation or disruption of cellular signal transduction by xenobiotics --
Disruption of mitochondrial function and mitochondria-mediated toxicity --
Novel mechanisms derived from systems toxicology.
Responsabilidad: Urs A. Boelsterli.
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'Students taking formal training in toxicology would definitely benefit from adding this book to their collection, since it covers many recent advances in the field.' - British Toxicology Society Leer más

 
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