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Medicinal chemistry : principles and practice

Author: Frank D King
Publisher: Cambridge : Royal Society of Chemistry, ©1994.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:

An introduction to the subject, aimed primarily at synthetic chemists, which explains how to identify a drug candidate from an initial lead compound that possesses the properties required for  Read more...

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Genre/Form: Congresses
Additional Physical Format: Online version:
Medicinal chemistry.
Cambridge : Royal Society of Chemistry, ©1994
(OCoLC)645919975
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Frank D King
ISBN: 9780851864945 0851864945
OCLC Number: 31423963
Notes: "Lectures presented at the 7th RSC Medicinal Chemistry School held between 28th June and 3rd July in 1993 at the University of Kent, Canterbury, UK"--Preface.
Description: xxi, 313 pages : illustrations
Contents: An introduction to drug-receptor interactions / Barry Hunt --
Signal transduction and second messengers / Trevor J. Franklin --
Enzyme inhibitors / David A. Roberts --
The biological evaluation of new compounds / Robert A. Coleman --
Pharmacokinetics / Robert M.J. Ings --
Drug metabolism / Colin Vose --
Physicochemical properties and drug design / Nigel P. Gensmantel --
Quantitative structure-activity relationships / Andrew M. Davis --
Considerations for the use of computational chemistry techniques by medicinal chemists / Mike M. Hann --
'Patent medicine' / Bill Tyrrell --
Molecular biology : a new route to drug discovery / Janet E. Carey --
Devising a research strategy / Colin W. Greengrass --
Past approaches to discovering new drugs as medicines / C. Robin Ganellin --
Bioisosteres, conformational restriction and pro-drugs : approaches to lead optimisation, case history : an example of a conformational restriction approach / Frank D. King --
The design and synthesis of selective protein kinase C inhibitors / Christopher H. Hill --
Discovery of 1069C : a novel synthetic antitumour agent with low cross-resistance potential / Simon T. Hodgson --
The design and biological properties of 'dipeptoid' antagonists / David C. Horwell --
Migraine therapy : from serotonin to sumatriptan / Peter C. North --
Drug development / Jane Ormerod.
Responsibility: edited by Frank D. King.

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"Overall an excellent book for those making a move into pharmaceutical/medicinal chemistry research and for those who wish to broaden their knowledge of all the disciplines involved in this area". * Read more...

 
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