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Medicinal chemistry strategies in combating antibiotic resistance

Author: Geoffrey D Coxon
Publisher: London : Henry Stewart Talks, 2009.
Series: Henry Stewart talks., Biomedical & life sciences collection., Antibiotic resistance : from genes to global prevalence.
Edition/Format:   eVideo : Clipart/images/graphics : EnglishView all editions and formats
Database:WorldCat
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Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: Geoffrey D Coxon
OCLC Number: 641344082
Notes: Animated audio-visual presentation with synchronized narration.
Title from title frames.
Description: 1 streaming video file (37 min.) : digital, mono, SWF file, sound, color.
Details: Mode of access: World Wide Web.; System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader 6.0+.
Contents: Overview of the drug discovery process --
Mechanisms of antibiotic action and resistance --
Modification of the antibiotic pharmacophore --
Modification of the target structure --
Targeting existing therapy and resistance mechanisms --
Overcoming modification in the target structure --
Considerations and methods in the discovery of new antibiotics --
Genomic based approaches --
Lead discovery approaches --
Fragment based drug discovery --
Modelling: ligand and structure known approach --
Modelling: structure known but ligand unknown approach --
Modelling: ligand known but structure unknown --
Whole cell (empirical) based approaches --
Selection of chemical starting points.
Series Title: Henry Stewart talks., Biomedical & life sciences collection., Antibiotic resistance : from genes to global prevalence.
Responsibility: Geoffrey D. Coxon.
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