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Meselson, Stahl, and the replication of DNA : a history of "the most beautiful experiment in biology "

Author: Frederic Lawrence Holmes
Publisher: New Haven, CT : Yale University Press, 2001.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:
"In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows  Read more...
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Named Person: Matthew Meselson; Franklin W Stahl; Matthew Meselson; Franklin W Stahl; Matthew Stanley Meselson; Franklin William Stahl; Matthew Stanley Meselson; Franklin William Stahl
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Frederic Lawrence Holmes
ISBN: 0300085400 9780300085402
OCLC Number: 45804765
Description: xii, 503 pages : illustrations ; 25 cm
Contents: The replication problem --
Meselson and Stahl --
Twists and turns --
Crossing fields: chemical bonds to biological mutants --
Dense solutions --
The big machine --
Working at high speed --
The unseen band --
One disvoery, three stories --
An extremely beautiful experiment --
Centrifugal forces --
The subunits of semiconservative replication --
Images of an experiment.
Responsibility: Frederic Lawrence Holmes.
More information:

Abstract:

"In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest." "This book reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment."--Jacket.

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