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Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i>
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Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus

Author: Diluka Peiris Affiliation: Fungal Biotechnology Group, School of Biosciences, The University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UKWarwick B Dunn Affiliation: Bioanalytical Sciences Group, School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, Princess St., Manchester, M1 7DN, UKMarie Brown Affiliation: Bioanalytical Sciences Group, School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, Princess St., Manchester, M1 7DN, UKDouglas B Kell Affiliation: Bioanalytical Sciences Group, School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, Princess St., Manchester, M1 7DN, UKIpsita Roy Affiliation: Fungal Biotechnology Group, School of Biosciences, The University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UKAll authors
Edition/Format: Article Article : English
Publication:Metabolomics, v4 n1 (200803): 52-62
Other Databases: WorldCatWorldCatWorldCat
Summary:
The paper presents the first proof-of principle study of metabolite profiles of the interacting mycelial fronts of a wood decomposer basidiomycete, Stereum hirsutum, paired with two competitor basidiomycetes, Coprinus disseminatus and C. micaceus, using TLC and GC-TOF-MS profiling. GC-TOF-MS profiles were information rich, with a total of 190 metabolite peaks detected and more than 120 metabolite peaks detected per sample. The metabolite profiles were able to discriminate between the interactions of S. hirsutum with the two species of Coprinus. In confrontation with C. micaceus, where S. hirsutum mycelial fronts always overgrew those of C. micaceus, there were down-regulations of metabolites in the interaction zone, compared to monocultures of both S. hirsutum and C. micaceus. In contrast, in pairings with C. disseminatus, whose mycelia overgrew those of S. hirsutum, there were some up-regulations compared with monoculture controls, the majority of the metabolites being characteristic of the S. hirsutum monoculture profile. These differences indicate that up-regulation of metabolites in the mycelia of S. hirsutum may be connected to a defensive role or to stress. The results also show proof of principle for the employment of metabolic profiling for biological discovery studies of metabolites produced by fungi that could be applied to natural product screening programmes.  Read more...
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Document Type: Article
All Authors / Contributors: Diluka Peiris Affiliation: Fungal Biotechnology Group, School of Biosciences, The University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK; Warwick B Dunn Affiliation: Bioanalytical Sciences Group, School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, Princess St., Manchester, M1 7DN, UK; Marie Brown Affiliation: Bioanalytical Sciences Group, School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, Princess St., Manchester, M1 7DN, UK; Douglas B Kell Affiliation: Bioanalytical Sciences Group, School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, Princess St., Manchester, M1 7DN, UK; Ipsita Roy Affiliation: Fungal Biotechnology Group, School of Biosciences, The University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK; John N Hedger Affiliation: Fungal Biotechnology Group, School of Biosciences, The University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK
ISSN:1573-3882
Language Note: English
Unique Identifier: 5660268948
Awards:

Abstract:

The paper presents the first proof-of principle study of metabolite profiles of the interacting mycelial fronts of a wood decomposer basidiomycete, Stereum hirsutum, paired with two competitor basidiomycetes, Coprinus disseminatus and C. micaceus, using TLC and GC-TOF-MS profiling. GC-TOF-MS profiles were information rich, with a total of 190 metabolite peaks detected and more than 120 metabolite peaks detected per sample. The metabolite profiles were able to discriminate between the interactions of S. hirsutum with the two species of Coprinus. In confrontation with C. micaceus, where S. hirsutum mycelial fronts always overgrew those of C. micaceus, there were down-regulations of metabolites in the interaction zone, compared to monocultures of both S. hirsutum and C. micaceus. In contrast, in pairings with C. disseminatus, whose mycelia overgrew those of S. hirsutum, there were some up-regulations compared with monoculture controls, the majority of the metabolites being characteristic of the S. hirsutum monoculture profile. These differences indicate that up-regulation of metabolites in the mycelia of S. hirsutum may be connected to a defensive role or to stress. The results also show proof of principle for the employment of metabolic profiling for biological discovery studies of metabolites produced by fungi that could be applied to natural product screening programmes.

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