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Metal complex-DNA interactions

Author: Nick D Hadjiliadis; Einar Sletten
Publisher: Chichester, West Sussex, U.K. : Wiley, 2009.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine." "Metal Complex-DNA Interactions provides a comprehensive overview of  Read more...
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Genre/Form: Aufsatzsammlung
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Nick D Hadjiliadis; Einar Sletten
ISBN: 9781405176293 1405176296
OCLC Number: 275864707
Description: xvii, 524 pages, [12] pages of plates : illustrations (some color) ; 25 cm
Contents: Sequence-selective binding of transition metal complexes to DNA / Einar Sletten and Nils Åge Frøystein --
Thermodynamic models of metal ion-DNA interactions / Vasil Bregadze, Eteri Gelagutashvili and Ketevan Tsakadze --
Metal ion coordination in G-quadruplexes / Janez Plavec --
Supramolecular chemistry of metal-nucleobase complexes / P.J. Sanze Miguel [and others] --
Platinum drugs, nucleotides and DNA : the role of interligand interactions / Giovanni Natile and Francesco Cannito --
Role of DNA repair in antitumour effects of platinum drugs / Viktor Brabec and Jana Kašpárková --
Telomeres and telomerase : potential targets for platinum complexes / Isabell Ourliac-Garnier, Razan Charif and Sophie Bombard --
Towards photodynamic therapy of cancer with platinum group metal polyazine complexes / David F. Zigler and Karen J. Brewer --
Platinated oligonucleotides : synthesis and applications for the control of gene expression / Vicente Marchán and Anna Grandas. Rhodium- and tin-DNA interactions and applications / Kenneth D. Camm and Patrick C. McGowan --
Groove-binding ruthenium(II) complexes as probes of DNA recognition / Jayden A. Smith, J. Grant Collins and F. Richard Keene --
DNA recognition and binding by peptide-metal complex conjugates / Alexandra Myari and Nick Hadjiliadis --
Artificial restriction agents : hydrolytic agents for DNA cleavage / Fabrizio Mancin and Paolo Tecilla --
New metallo-DNAzymes : fundamental studies of metal-DNA interactions and metal sensing applications / Zehui Cao and Yi Lu --
Two-metal-ion-dependent catalysis in nucleic acid enzymes / Wei Yang --
Structural studies on the mercury-mediated T-T base-pair using NMR spectroscopy / Yoshiyuki Tanaka and Akira Ono --
Chromium-induced DNA damage and repair / Laura G. Little and Kent D. Sugden --
Arsenic induced carcinogenicity : new insights in molecular mechanism / Andrea Hartwig and Tanja Schwerdtle.
Responsibility: edited by Nick Hadjiliadis and Einar Sletten.

Abstract:

Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents.  Read more...

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"An impressive overview of the great diversity of current research." (Angewandte Chemie International Edition, February 2010) "An essential part of the library for laboratories involved in Read more...

 
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