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Metal Toxicology : Approaches and Methods.

Author: Robert A Goyer
Publisher: Burlington : Elsevier Science, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time. Unique aspect of organ-specific  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Goyer, Robert A.
Metal Toxicology : Approaches and Methods.
Burlington : Elsevier Science, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Robert A Goyer
ISBN: 9781483288567 1483288560
OCLC Number: 904404451
Notes: Iv. mercury effects on the immune system.
Description: 1 online resource (550 pages)
Contents: Front Cover; Metal Toxicology; Copyright Page; Table of Contents; Contributors; Preface; PART I: GENERAL PRINCIPLES; Chapter 1. Metal Disposition: An Analysis of Underlying Mechanisms; I. INTRODUCTION; II. METAL ABSORPTION; III. TRANSPORT OF TNEM IN BLOOD; IV. MECHANISM OF CELLULAR TNEM UPTAKE IN TARGET ORGANS; V. CELLULAR TRAPPING OF TNEM AND THEIR RELEASE; VI. EXCRETION OF TNEM; VII. APPROACH TO STEADY STATE: TOXICOLOGICAL IMPLICATIONS; VIII. CONCLUSIONS; REFERENCES; Chapter 2. Factors Influencing Metal Toxicity; I. INTRODUCTION; II. ESSENTIAL METALS; III. METAL-BINDING PROTEINS. IV. ETHANOLV. AGE AND DEVELOPMENT; VI. GENETICS; REFERENCES; Chapter 3. Metal Carcinogenesis; I. INTRODUCTION; II. CHARACTERISTICS OF METALS AS TOXINS OR CARCINOGENS; III. PROBLEMS IN ASSESSING CARCINOGENIC RISK FROM METALS; IV. METALS AS HUMAN CARCINOGENS; V. METALS AS CARCINOGENS IN ANIMALS; VI. TARGET SITES OF THE CARCINOGENIC METALS; VII. TARGET SITE SPECIFICITY IN METAL CARCINOGENESIS; VIII. DUALITIES IN METAL CARCINOGENESIS; IX. HYPOTHETICAL MECHANISMS IN METAL CARCINOGENESIS; X. METAL-METAL INTERACTIONS IN METAL CARCINOGENESIS; XI. SUMMARY; REFERENCES. Chapter 4. Organ-Specific Therapeutic InterventionI. INTRODUCTION; II. BLOOD, MARROW, BONE; III. IMMUNOTOXICITY; IV. LIVER TOXICITY; V. KIDNEY; VI. NEUROTOXICITY; VII. CARDIOVASCULAR; VIII. RESPIRATORY; IX. SKIN TOXICITY; X. REPRODUCTIVE TOXICITY; REFERENCES; Chapter 5. Molecular Techniques in Metal Toxicology; I. INTRODUCTION; II. MEASURING GENETIC CHANGES IN RESPONSE TO METALS; III. INTERVENTION IN CONTROL OF GENE EXPRESSION IN EUKARYOTES; IV. CELLULAR RESPONSE TO INTERVENTION IN GENE EXPRESSION; V. SUMMARY; ACKNOWLEDGMENT; REFERENCES; Chapter 6. Risk Assessment; I. INTRODUCTION. II. HAZARD IDENTIFICATIONIII. DOSE-RESPONSE ASSESSMENT; IV. EXPOSURE ASSESSMENT; V. RISK CHARACTERIZATION; VI. USE OF RISK ASSESSMENT FOR METALS IN THE REGULATORY PROCESS; VII. CONCLUSIONS; REFERENCES; Chapter 7. Toxic Metals in Emerging Technologies; I. INTRODUCTION; II. CHEMICAL DISPOSITION STUDIES; III. BIOLOGICAL EFFECTS; IV. FUTURE RESEARCH DIRECTIONS; ACKNOWLEDGEMENTS; REFERENCES; PART II: TARGET ORGANS; Chapter 8. Nervous System; I. INTRODUCTION; II. INORGANIC AND ORGANIC MERCURY; III. INORGANIC AND ORGANIC LEAD; IV. ALUMINUM; V. TIN; VI. TELLURIUM; VII. ARSENIC; VIII. MANGANESE.

Abstract:

Metal Toxicology addresses the effects of metals on human health, as well as their mechanisms of toxicity. Unlike most books on metal toxicity which are organized by individual metals, this book is arranged inan organ-by-organ basis. It deals with unifying mechanisms of metal toxicity within a given tissue, and with exposure of a tissue to more than one metal at a time. Unique aspect of organ-specific orientationWritten by leading authorities in metal toxicologyChapters of special interest include Risk Assessment, Emerging Technologies, and Molecular Biological TechniquesServes as an excellent.

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