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Metalloproteinases as Targets for Anti-Inflammatory Drugs

Author: Kevin M K Bottomley; David Bradshaw; John S Nixon
Publisher: Basel : Birkhäuser Basel : Imprint : Birkhäuser, 1999.
Series: PIR (Series)
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume is intended not only for those active in research into  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Kevin M K Bottomley; David Bradshaw; John S Nixon
ISBN: 9783034886666 3034886667
OCLC Number: 851808214
Description: 1 online resource (xii, 207 pages).
Contents: Structural characteristics of the matrix metalloproteinases --
Matrix metalloproteinase inhibitors --
Role of stromelysin-1 in cartilage metabolism --
Matrix metalloproteinases in neuro-inflammatory disease --
Membrane type matrix metalloproteinases: Regulators of focal proteolysis --
Aggrecanase and cartilage proteoglycan degradation --
Overview of the biological roles of metalloproteinases in health and disease --
Adhesion molecule sheddases --
TNF? converting enzyme.
Series Title: PIR (Series)
Responsibility: edited by Kevin M.K. Bottomley, David Bradshaw, John S. Nixon.
More information:

Abstract:

This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume is intended not only for those active in research into metalloproteinases but also for those with an interest in inflammatory diseases. Thus it addresses both academic and industrial researchers.

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