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Methodological approaches influencing cellular uptake and cyto-(geno) toxic effects of nanoparticles.

Author: UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology; Gonzalez, Laetitia; Corradi, Sara; Thomassen, Leen C J; Martens, Johan A; Cundari, Enrico; Lison, Dominique; Kirsch-Volders, Micheline
Publisher: 2011
Edition/Format:   Downloadable archival material : English
Database:WorldCat
Summary:
Methods are needed to assess cytotoxicity and genotoxicity of nanoparticles (NPs). The influence of serum and the use of cytochalasin-B were assessed on the cellular uptake of amorphous silica NPs (SNPs) and their biological effects. Our observations indicate that some methodological approaches may modulate the outcome of the assay. Therefore the experimental design and choice of the assays are of great importance  Read more...
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Genre/Form: Article de périodique (Journal article)
Material Type: Internet resource
Document Type: Internet Resource, Archival Material
All Authors / Contributors: UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology; Gonzalez, Laetitia; Corradi, Sara; Thomassen, Leen C J; Martens, Johan A; Cundari, Enrico; Lison, Dominique; Kirsch-Volders, Micheline
OCLC Number: 870002295
Language Note: English

Abstract:

Methods are needed to assess cytotoxicity and genotoxicity of nanoparticles (NPs). The influence of serum and the use of cytochalasin-B were assessed on the cellular uptake of amorphous silica NPs (SNPs) and their biological effects. Our observations indicate that some methodological approaches may modulate the outcome of the assay. Therefore the experimental design and choice of the assays are of great importance in nanotoxicology.

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