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MHC class I antigens in malignant cells : immune escape and response to immunotherapy

Author: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
Publisher: New York, NY : Springer, ©2013.
Series: SpringerBriefs in cancer research, 6.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
ISBN: 9781461465430 1461465435
OCLC Number: 829679127
Description: 1 online resource.
Contents: Overview of MHC Class I Antigens --
HLA Class I Expression in Human Cancer --
MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns --
Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression --
Conclusions.
Series Title: SpringerBriefs in cancer research, 6.
Responsibility: Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.
More information:

Abstract:

This book discusses abnormal expression of MHC class I molecules in malignant cells, explaining how MHC class 1 is expressed, and its role in tumor progression. Includes new discoveries by the  Read more...

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