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MHC class I antigens in malignant cells : immune escape and response to immunotherapy

Autor: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
Editorial: New York, NY : Springer, ©2013.
Serie: SpringerBriefs in cancer research, 6.
Edición/Formato:   Libro-e : Documento : Inglés (eng)Ver todas las ediciones y todos los formatos
Base de datos:WorldCat
Resumen:
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies  Leer más
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Detalles

Género/Forma: Electronic books
Tipo de material: Documento, Recurso en Internet
Tipo de documento: Recurso en Internet, Archivo de computadora
Todos autores / colaboradores: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
ISBN: 9781461465430 1461465435
Número OCLC: 829679127
Descripción: 1 online resource.
Contenido: Overview of MHC Class I Antigens --
HLA Class I Expression in Human Cancer --
MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns --
Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression --
Conclusions.
Título de la serie: SpringerBriefs in cancer research, 6.
Responsabilidad: Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.
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Resumen:

This book discusses abnormal expression of MHC class I molecules in malignant cells, explaining how MHC class 1 is expressed, and its role in tumor progression. Includes new discoveries by the  Leer más

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Datos enlazados


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