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MHC class I antigens in malignant cells : immune escape and response to immunotherapy

Auteur : Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
Éditeur : New York, NY : Springer, ©2013.
Collection : SpringerBriefs in cancer research, 6.
Édition/format :   Livre électronique : Document : EnglishVoir toutes les éditions et tous les formats
Base de données :WorldCat
Résumé :
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies  Lire la suite...
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Genre/forme : Electronic books
Type d’ouvrage : Document, Ressource Internet
Format : Internet Resource, Computer File
Tous les auteurs / collaborateurs : Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
ISBN : 9781461465430 1461465435 1299693784 9781299693784
Numéro OCLC : 829679127
Description : 1 online resource.
Contenu : Overview of MHC Class I Antigens --
HLA Class I Expression in Human Cancer --
MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns --
Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression --
Conclusions.
Titre de collection : SpringerBriefs in cancer research, 6.
Responsabilité : Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.
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Résumé :

This book discusses abnormal expression of MHC class I molecules in malignant cells, explaining how MHC class 1 is expressed, and its role in tumor progression. Includes new discoveries by the  Lire la suite...

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