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MHC class I antigens in malignant cells : immune escape and response to immunotherapy

Autor: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
Editora: New York, NY : Springer, ©2013.
Séries: SpringerBriefs in cancer research, 6.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies  Ler mais...
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Detalhes

Gênero/Forma: Electronic books
Tipo de Material: Documento, Recurso Internet
Tipo de Documento: Recurso Internet, Arquivo de Computador
Todos os Autores / Contribuintes: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
ISBN: 9781461465430 1461465435 1299693784 9781299693784
Número OCLC: 829679127
Descrição: 1 online resource.
Conteúdos: Overview of MHC Class I Antigens --
HLA Class I Expression in Human Cancer --
MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns --
Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression --
Conclusions.
Título da Série: SpringerBriefs in cancer research, 6.
Responsabilidade: Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.

Resumo:

This book discusses abnormal expression of MHC class I molecules in malignant cells, explaining how MHC class 1 is expressed, and its role in tumor progression. Includes new discoveries by the  Ler mais...

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