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MHC class I antigens in malignant cells : immune escape and response to immunotherapy

著者: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
出版商: New York, NY : Springer, ©2013.
丛书: SpringerBriefs in cancer research, 6.
版本/格式:   电子图书 : 文献 : 英语查看所有的版本和格式
数据库:WorldCat
提要:
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies  再读一些...
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类型/形式: Electronic books
材料类型: 文献, 互联网资源
文件类型: 互联网资源, 计算机文档
所有的著者/提供者: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
ISBN: 9781461465430 1461465435
OCLC号码: 829679127
描述: 1 online resource.
内容: Overview of MHC Class I Antigens --
HLA Class I Expression in Human Cancer --
MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns --
Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression --
Conclusions.
丛书名: SpringerBriefs in cancer research, 6.
责任: Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.

摘要:

This book discusses abnormal expression of MHC class I molecules in malignant cells, explaining how MHC class 1 is expressed, and its role in tumor progression. Includes new discoveries by the  再读一些...

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