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MHC Class I Antigens In Malignant Cells : Immune Escape And Response To Immunotherapy

Author: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Series: SpringerBriefs in Cancer Research, 6.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence℗¡that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches.℗¡A complete characterization of these molecular defects is important for improvement of the strategies  Read more...
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Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Natalia Aptsiauri; Angel Miguel Garcia-Lora; Teresa Cabrera
ISBN: 9781461465430 1461465435
OCLC Number: 890437312
Description: 1 online resource (VIII, 51 p. 17 illus., 14 illus. in color.) online resource.
Contents: Overview of MHC Class I Antigens --
HLA Class I Expression In Human Cancer --
MHC Class I Expression In Experimental Mouse Models Of Cancer: Immunotherapy Of Tumors With Different MHC-I Expression Patterns --
Potential Therapeutic Approaches For Increasing Tumor Immunogenicity By Upregulation Of Tumor HLA Class I Expression --
Conclusion.
Series Title: SpringerBriefs in Cancer Research, 6.
Responsibility: by Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.

Abstract:

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence℗¡that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches.℗¡A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. ℗¡Precise identification of the mechanism leading to MHC class I defects ℗¡will help to develop new personalized patient-tailored treatment protocols.℗¡There is significant new research℗¡on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is℗¡available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that℗¡show℗¡the℗¡progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on℗¡determining the final outcome of cancer immunotherapy.℗¡This SpringerBrief will present℗¡how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. ℗¡

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