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MicroRNA : medical evidence from molecular biology to clinical practice

Author: Gaetano Santulli
Publisher: Cham : Springer International Publishing, [2015] ©2015
Series: Advances in experimental medicine and biology, Volume 888.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today?s initiatives towards precision medicine. The following chapters explore the clinical role  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Santulli, Gaetano.
MicroRNA: Medical Evidence.
Cham : Springer International Publishing, ©2016
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gaetano Santulli
ISBN: 9783319226712 3319226711 3319226703 9783319226705
OCLC Number: 932198381
Description: 1 online resource (xii, 429 pages).
Contents: Foreword; Contents; Contributors; Chapter 1: Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine; References; Chapter 2: microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers; microRNA Biogenesis; microRNA Deregulation in Cancers; Specific Advantages of microRNAs in Cancer Diagnosis; Challenges in microRNA-Based Diagnosis; Conclusion; References; Chapter 3: microRNA and Pain; Introduction; miRNAs in Acute Pain; miRNAs in Neuropathic Pain: The Peripheral Nervous System. MiRNAs in Neuropathic Pain: The Spinal Cord miRNAs in Inflammation-Induced Superficial Pain; miRNAs in Arthritic Pain; miRNAs in Visceral Pain; miRNAs in Cancer Pain; miRNAs in Other Pain Conditions; Brain miRNAs in Pain Conditions; Other Noncoding RNAs in Pain; miRNA Potential for Clinical Application in Pain; References; Chapter 4: microRNA and Epilepsy; Introduction; Epilepsy; Epidemiology; Diagnosis; Treatment; Experimental Models of Epilepsy; Kainic Acid; Pilocarpine; Pentylenetetrazole; Kindling; Mechanisms Underlying Epilepsy; Genetic Mutations; Acquired Epilepsy. Neuronal Cell Loss Neuroinflammation: Microglia and Astrocyte Activation; BBB Disruption; Neuronal Plasticity; microRNAs and CNS; microRNA Biogenesis and Mechanisms of Action; miRNAs Regulate Key Processes in Epilepsy; miRNA Profiling in Status Epilepticus and Epilepsy; Molecular Mechanisms of miRNA Expression Control in Epilepsy; miRNA and Epilepsy: An Overview About Functional Studies; miRNA as Biomarkers of Epilepsy; Conclusion; References; Chapter 5: microRNA and Autism; Introduction; Genetic Architecture of Autism Is Complex; microRNAs in Neurodevelopment; Circulating miRNAs. MiRNAs in Neurological Disorders miRNAs in Autism; Therapeutic Potential of miRNAs; Future Directions; References; Chapter 6: microRNAs and Neurodegenerative Diseases; Introduction; miRNA in Neurodegenerative Diseases; miRNAs and AD; Dysregulation of miRNA in AD; miR-9 in AD; miR-29 in AD; miRNA let-7b in AD; miR-106b in AD; miRNAs and PD; Dysregulation of miRNA in PD; miR-133b in PD; miR-107 in PD; miR-34 in PD; miR-205 in PD; miRNAs and HD; Dysregulated miRNA in HD; miR-9 in HD; miR-22 in HD; miR-128 in HD; miR-132 in HD; miRNAs and ALS; Dysregulated miRNA in ALS. MiR-206 in ALSmiR-155 in ALS; Therapeutic Potential of miRNAs in Neurodegenerative Diseases; Development of miRNA-Based Therapeutics; Development of Anti-microRNA-Based Therapeutics; Antisense Oligonucleotides; Antagomirs; miRNA Sponge; Locked Nucleic Acid; Development of miRNA Biogenesis-Based Therapeutics; Challenge of Delivering Therapeutic miRNA Targets in NDDs; Crossing the BBB to Deliver Therapeutics miRNA Targets; Exosome; Non-viral; Viral; Toxicity and Off-Target Effects of Delivering Therapeutic miRNA Targets; Conclusion; References; Chapter 7: microRNAs and Fragile X Syndrome.
Series Title: Advances in experimental medicine and biology, Volume 888.
Responsibility: Gaetano Santulli, editor.

Abstract:

This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules.  Read more...

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