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Microtubule Targets in Cancer Therapy.

Author: Antonio Tito Fojo
Publisher: Dordrecht : Springer, 2008.
Series: Cancer drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This title presents an exploration of the dynamic potential of microtubules anti-cancer targets.
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Antonio Tito Fojo
ISBN: 9781597453363 1597453366
OCLC Number: 437104720
Description: 1 online resource (636 pages).
Contents: An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly; Molecular Mechanisms of Microtubule Acting Cancer Drugs; Microtubule Dynamics; Microtubule-Associated Proteins and Microtubule-Interacting Proteins; The Post-Translational Modifications of Tubulin; The Isotypes of Tubulin; The Tubulin Superfamily; Tubulin Proteomics in Cancer; Tubulin and Microtubule Structures; Destabilizing Agents; Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin; Antimicrotubule Agents That Bind Covalently to Tubulin. Microtubule Stabilizing AgentsMechanisms of Resistance to Drugs That Interfere with Microtubule Assembly; Resistance to Microtubule-Targeting Drugs; Microtubule Stabilizing Agents in Clinical Oncology; Investigational Anticancer Agents Targeting the Microtubule; Microtubule Damaging Agents and Apoptosis; Microtubule Targeting Agents and the Tumor Vasculature; Neurodegenerative Diseases; Structure, Function, and Regulation of the Microtub.
Series Title: Cancer drug discovery and development.

Abstract:

The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This title presents an exploration of the dynamic potential of microtubules anti-cancer targets.

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