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Modafinil for sleep disorders and fatigue secondary to multiple sclerosis : a review of the clinical efficacy and safety

Author: Canadian Agency for Drugs and Technologies in Health.
Publisher: [Ottawa, Ont.] : Canadian Agency for Drugs and Technologies in Health, 2012.
Series: Rapid response report.
Edition/Format:   eBook : Document : English
Database:WorldCat
Summary:
Modafinil is a central nervous system stimulant approved in Canada for the symptomatic treatment of excessive sleepiness in adult patients with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. Its efficacy has also tested in a number of off-label conditions such as fatigue related to multiple sclerosis (MS) or Parkinson's disease, cocaine addiction, attention deficit disorder, and depression.  Read more...
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Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Canadian Agency for Drugs and Technologies in Health.
OCLC Number: 818083738
Notes: "27 July 2012."
Description: 1 online resource (15 pages) : tables, digital file.
Contents: Pages:1 to 8; Pages:9 to 15.
Series Title: Rapid response report.
Responsibility: [prepared by Canadian Agency for Drugs and Technologies in Health].
More information:

Abstract:

Modafinil is a central nervous system stimulant approved in Canada for the symptomatic treatment of excessive sleepiness in adult patients with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. Its efficacy has also tested in a number of off-label conditions such as fatigue related to multiple sclerosis (MS) or Parkinson's disease, cocaine addiction, attention deficit disorder, and depression. Modafinil's mechanism of action of promoting wakefulness is not known, but it has a different pharmacologic profile than other stimulants used in sleep disorders, namely methylphenidate or amphetamines. This report will review the safety and efficacy of modafinil in patients with sleep disorders, or fatigue due to MS, in order to inform funding decisions.

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