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Modeling Autism Spectrum Disorders Using Human Neurons

Author: Alysson Renato Muotri Affiliation: Department of Pediatrics/Rady Children’s Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, 2880 Torrey Pines Scenic Road - Sanford Consortium, Room 3005, 92093, La Jolla, CA, MC 0695, USA
Edition/Format: Chapter Chapter : English
Database:SpringerLink
Summary:
The cellular and molecular mechanisms of neurodevelopmental conditions such as autism spectrum disorders (ASDs) have been studied intensively for decades. The unavailability of live patient neurons for research, however, has represented a major obstacle in the elucidation of the disease etiologies. The generation of human neurons from induced pluripotent stem cells (iPSCs) derived from patients with ASDs offers a  Read more...
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All Authors / Contributors: Alysson Renato Muotri Affiliation: Department of Pediatrics/Rady Children’s Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, 2880 Torrey Pines Scenic Road - Sanford Consortium, Room 3005, 92093, La Jolla, CA, MC 0695, USA
ISBN: 978-3-642-36647-5 978-3-642-36648-2
Publication:Gage, Fred H., 858 453 4100, gage@salk.edu, , Laboratory of Genetics, The Salk Institute f. Biological Studies, North Torrey Pines Road 10010, La Jolla, California, 92037, USA; Programmed Cells from Basic Neuroscience to Therapy; 101-117; Berlin, Heidelberg : Springer Berlin Heidelberg : Springer
Language Note: English
Unique Identifier: 5661010632
Awards:

Abstract:

The cellular and molecular mechanisms of neurodevelopmental conditions such as autism spectrum disorders (ASDs) have been studied intensively for decades. The unavailability of live patient neurons for research, however, has represented a major obstacle in the elucidation of the disease etiologies. The generation of human neurons from induced pluripotent stem cells (iPSCs) derived from patients with ASDs offers a novel and complementary opportunity for basic research and the development of therapeutic compounds aiming to revert or ameliorate the condition. The findings of relevant phenotypes in Rett syndrome iPSC-derived neurons suggest that iPSC technology offers a novel and unique opportunity for understanding and developing therapeutics for other ASDs. Neurons-in-a-dish from syndromic forms of ASD open new avenues for the stratification of different subtypes of idiopathic autism. In this chapter, I will discuss the conceptual and practical issues related to modeling ASD using human neurons.

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