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Modulation of presynaptic calcium channels

Author: Gary Stephens; Sumiko Mochida
Publisher: Dordrecht ; New York : Springer, ©2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gary Stephens; Sumiko Mochida
ISBN: 9789400763340 9400763344 9400763336 9789400763333
OCLC Number: 841761938
Notes: Includes index.
Description: 1 online resource
Contents: Foreword: Gary Stephens Overview 1. Spatial and temporal regulation of Ca2+ channels; Sumiko Mochida Interaction partners of calcium channels 2. Neuronal functions of auxiliary calcium channel subunits; Gerald Obermair and Bernd Flucher 3. Reciprocal regulation of neuronal calcium channels by synaptic proteins; Norbert Weiss and Gerald Zamponi 4. Molecular architecture of Ca2+ channel complexes organized by beta subunits in presynaptic active zones; Akito Nakao, Mitsuru Hirano, Yoshinori Takada, Shigeki Kiyonaka and Yasuo Mori 5. Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors; Mark L. Jewell and Kevin P.M. Currie 6. Regulation of CaV2 channels by small GTPases; Pierre Charnet, Frederique Scamps, Matthieu Rousset, Claudine Menard, Michel Bellis and Thierry Cens 7. Protein interaction partners of Cav2.3 R-type voltage-gated calcium channels; Maxine Dibue, Etienne E. Tevoufouet, Andreas Krieger, Alexandra Kiel, Dimitar Evdokimov, Thomas Galetin, Serdar Alpdogan, Isha Akhtar, Sabrina Scharf, Renate Clemens, Kayalvizhi Radhakrishnan, Jurgen Hescheler, Toni Schneider, Marcel A. Kamp 8. Voltage-gated calcium channel signaling to the nucleus; Michel Bellis, Thierry Cens, Claudine Menard, Pierre Charnet and Matthieu Rousset Mechanisms of studying calcium channel effects 9. Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals; Holger Taschenberger, Kun-Han Lin and Shuwen Chang 10. Use of synthetic Ca2+ channel peptides to study presynaptic function; Giovanna Bucci, Sumiko Mochida and Gary Stephens Calcium channel therapeutics 11. Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons; David Friel 12. CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases; Osvaldo Uchitel 13. Splicing and editing to customize CaV channel structures for optimal neural function; Hua Huang, Juejin Wang and Tuck Wah Soong 14. Presynaptic calcium channels as drug targets for pain; Edward Stevens and Peter Fox 15. Sensory pathway modulation by calcium channel a2d1 subunit; Chunyi Zhou and Z. David Luo Index
Responsibility: Gary Stephens, Sumiko Mochida, editors.


This book presents recent advances in knowledge of the regulation of presynaptic Ca2+ channels. These represent one of the most widely modulated proteins in the body, target of a range of effector  Read more...
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