skip to content
Molecular and Biochemical Toxicology Preview this item
ClosePreview this item
Checking...

Molecular and Biochemical Toxicology

Author: Robert C Smart; Ernest Hodgson
Publisher: Hoboken : Wiley, 2008.
Edition/Format:   Print book : Document   Computer File : English : 4th ed
Summary:
An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Material Type: Document
Document Type: Book, Computer File
All Authors / Contributors: Robert C Smart; Ernest Hodgson
ISBN: 1118679725 9781118679722 1281732508 9781281732507 9786611732509 6611732500 0470285257 9780470285251 0470285249 9780470285244
OCLC Number: 1002508692
Language Note: English.
Notes: Description based upon print version of record.
5.3 Diagnostics and Functional Genomics
Description: 1 online resource (948 p.)
Contents: MOLECULAR AND BIOCHEMICAL TOXICOLOGY; CONTENTS; Preface; Contributors; 1. Molecular and Biochemical Toxicology: Definition and Scope; 1.1 Introduction; 1.2 Toxicology; 1.3 Biochemical Toxicology; 1.4 Cellular Toxicology; 1.5 Molecular Toxicology; 1.6 Proteomics and Metabolomics; 1.7 Conclusions; Suggested Reading; 2. Overview of Molecular Techniques in Toxicology: Genes and Transgenes; 2.1 Applicability of Molecular Techniques to Toxicology; 2.2 Overview of the Genetic Code and Flow of Genetic Information; 2.3 Molecular Cloning; 2.3.1 Vectors 2.3.2 Identification of Bacterial Colonies that Contain Recombinant DNA2.3.3 Construction of cDNA Library; 2.4 Southern and Northern Blot Analyses; 2.5 Polymerase Chain Reaction (PCR); 2.6 Some Methods to Evaluate Gene Expression and Regulation; 2.6.1 Northern Analysis; 2.6.2 Nuclear Run-On; 2.6.3 Promoter Deletion Analysis/Reporter Gene Assays; 2.6.4 Microarrays; 2.6.5 Reverse Transcriptase-PCR (RT-PCR) and Real-Time PCR; 2.6.6 RNase Protection (RPA); 2.6.7 Electrophoretic Mobility Shift Assay (EMSA); 2.7 Methods to Evaluate Gene Function; 2.7.1 Eukaryotic Expression Systems 2.7.2 Transgenic Mice2.7.2a Procedure for Making Transgenic Mice Using Zygote Injection; 2.7.2b Procedure for Making Knockout Mice Using Embryonic Stem Cells; 2.7.2c Conditional Knockout; 2.7.2d Cre-loxP Recombination System; Suggested Reading; 3. Toxicogenomics; 3.1 Introduction; 3.2 A Primer of Genomics; 3.3 Tools and Approaches; 3.4 Genomes; 3.5 Functional Genomics; 3.5.1 Microarrays; 3.5.1a Wet and Dry Lab Procedures; 3.5.1b Expression Profiling; 3.5.2 DNA Arrays; 3.5.2a Comparative Genomic Hybridizations; 3.5.2b SNP Discovery; 3.5.2c ChIP on Chip; 3.6 Conclusions; Suggested Reading 4. Proteomics4.1 Introduction to Proteomics; 4.1.1 Attributes of Proteins; 4.1.2 History of Proteomics; 4.2 Properties of Proteins; 4.2.1 Posttranslational Modifications; 4.2.2 Mass and Charge; 4.3 Fields of Proteomic Research; 4.4 Mass Spectrometers and Protein Identification; 4.4.1 Ionization Sources; 4.4.2 MALDI-TOF and Peptide Fingerprints; 4.4.3 ESI-MS/MS, LC-MS/MS, and Sequence Tags; 4.4.4 Mass Spectrometers: Three Components; 4.4.5 Mass Analyzers; 4.5 Proteomic Platforms; 4.5.1 Two-Dimensional Gel Separation or DIGE and Mass Spectrometry; 4.5.2 MudPIT; 4.5.3 ICAT, SILAC, iTRAQ 4.5.4 Retentate Chromatography Mass Spectrometry (RC-MS)4.5.5 Antibody Arrays; 4.5.6 Advantages and Disadvantages of Proteomic Platforms; 4.6 Proteomes and Subproteomes: Expectations and Reality; 4.7 Summary; Suggested Reading; 5. Metabolomics; 5.1 Introduction; 5.1.1 Definitions; 5.1.2 Nonbiased Approaches in Metabolomics; 5.1.3 Pipelined Approaches in Metabolomics; 5.2 Methods; 5.2.1 Mass Spectrometry; 5.2.1a Ionization; 5.2.1b Mass Selection and Ion Detection; 5.2.2 Nuclear Magnetic Resonance Spectroscopy; 5.2.2a Theory; 5.2.2b The NMR Spectrum; 5.2.3 NMR and Metabolomics
Other Titles: Molecular and Biochemical Toxicology, Fourth Edition

Abstract:

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes h.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1002508692> # Molecular and Biochemical Toxicology
    a schema:MediaObject, schema:Book, schema:CreativeWork ;
    library:oclcnum "1002508692" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/4479764439#Place/hoboken> ; # Hoboken
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/chemistry> ; # Chemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/biological_science_disciplines> ; # Biological Science Disciplines
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/metabolism> ; # Metabolism
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/toxicology> ; # Toxicology
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/public_health> ; # Public Health
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/toxicology_&_public_health> ; # Toxicology & Public Health
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/chemicals_and_drugs> ; # Chemicals and Drugs
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/biochemical_toxicology> ; # Biochemical toxicology
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/methods> ; # Methods
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/genetics> ; # Genetics
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/poisons> ; # Poisons
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/poisoning_metabolism> ; # Poisoning - metabolism
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/molecular_biology> ; # Molecular Biology
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/biology> ; # Biology
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/investigative_techniques> ; # Investigative Techniques
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/diseases> ; # Diseases
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/chemical_actions_and_uses> ; # Chemical Actions and Uses
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/specialty_uses_of_chemicals> ; # Specialty Uses of Chemicals
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/biochemistry> ; # Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/health_occupations> ; # Health Occupations
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/poisoning> ; # Poisoning
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/molecular_biology_methods> ; # Molecular Biology - methods
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/disciplines_and_occupations> ; # Disciplines and Occupations
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/substance_related_disorders> ; # Substance-Related Disorders
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/noxae> ; # Noxae
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/natural_science_disciplines> ; # Natural Science Disciplines
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/health_&_biological_sciences> ; # Health & Biological Sciences
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/pharmacology> ; # Pharmacology
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/phenomena_and_processes> ; # Phenomena and Processes
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/analytical_diagnostic_and_therapeutic_techniques_and_equipment> ; # Analytical, Diagnostic and Therapeutic Techniques and Equipment
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/toxic_actions> ; # Toxic Actions
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/poisons_metabolism> ; # Poisons - metabolism
    schema:about <http://dewey.info/class/615.9/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/toxicology_methods> ; # Toxicology - methods
    schema:about <http://experiment.worldcat.org/entity/work/data/4479764439#Topic/metabolic_phenomena> ; # Metabolic Phenomena
    schema:alternateName "Molecular and Biochemical Toxicology, Fourth Edition" ;
    schema:bookEdition "4th ed." ;
    schema:bookFormat bgn:PrintBook ;
    schema:contributor <http://experiment.worldcat.org/entity/work/data/4479764439#Person/hodgson_ernest> ; # Ernest Hodgson
    schema:creator <http://experiment.worldcat.org/entity/work/data/4479764439#Person/smart_robert_c> ; # Robert C. Smart
    schema:datePublished "2008" ;
    schema:description "MOLECULAR AND BIOCHEMICAL TOXICOLOGY; CONTENTS; Preface; Contributors; 1. Molecular and Biochemical Toxicology: Definition and Scope; 1.1 Introduction; 1.2 Toxicology; 1.3 Biochemical Toxicology; 1.4 Cellular Toxicology; 1.5 Molecular Toxicology; 1.6 Proteomics and Metabolomics; 1.7 Conclusions; Suggested Reading; 2. Overview of Molecular Techniques in Toxicology: Genes and Transgenes; 2.1 Applicability of Molecular Techniques to Toxicology; 2.2 Overview of the Genetic Code and Flow of Genetic Information; 2.3 Molecular Cloning; 2.3.1 Vectors"@en ;
    schema:description "An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes h."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4479764439> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isSimilarTo <http://worldcat.org/entity/work/data/4479764439#CreativeWork/> ;
    schema:name "Molecular and Biochemical Toxicology"@en ;
    schema:productID "1002508692" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/1002508692#PublicationEvent/hoboken_wiley_2008> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/4479764439#Agent/wiley> ; # Wiley
    schema:workExample <http://worldcat.org/isbn/9786611732509> ;
    schema:workExample <http://worldcat.org/isbn/9781118679722> ;
    schema:workExample <http://worldcat.org/isbn/9780470285251> ;
    schema:workExample <http://worldcat.org/isbn/9781281732507> ;
    schema:workExample <http://worldcat.org/isbn/9780470285244> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1002508692> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4479764439#Person/hodgson_ernest> # Ernest Hodgson
    a schema:Person ;
    schema:familyName "Hodgson" ;
    schema:givenName "Ernest" ;
    schema:name "Ernest Hodgson" ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Person/smart_robert_c> # Robert C. Smart
    a schema:Person ;
    schema:familyName "Smart" ;
    schema:givenName "Robert C." ;
    schema:name "Robert C. Smart" ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/analytical_diagnostic_and_therapeutic_techniques_and_equipment> # Analytical, Diagnostic and Therapeutic Techniques and Equipment
    a schema:Intangible ;
    schema:name "Analytical, Diagnostic and Therapeutic Techniques and Equipment"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/biochemical_toxicology> # Biochemical toxicology
    a schema:Intangible ;
    schema:name "Biochemical toxicology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/biological_science_disciplines> # Biological Science Disciplines
    a schema:Intangible ;
    schema:name "Biological Science Disciplines"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/chemical_actions_and_uses> # Chemical Actions and Uses
    a schema:Intangible ;
    schema:name "Chemical Actions and Uses"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/chemicals_and_drugs> # Chemicals and Drugs
    a schema:Intangible ;
    schema:name "Chemicals and Drugs"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/disciplines_and_occupations> # Disciplines and Occupations
    a schema:Intangible ;
    schema:name "Disciplines and Occupations"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/health_&_biological_sciences> # Health & Biological Sciences
    a schema:Intangible ;
    schema:name "Health & Biological Sciences"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/health_occupations> # Health Occupations
    a schema:Intangible ;
    schema:name "Health Occupations"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/investigative_techniques> # Investigative Techniques
    a schema:Intangible ;
    schema:name "Investigative Techniques"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/metabolic_phenomena> # Metabolic Phenomena
    a schema:Intangible ;
    schema:name "Metabolic Phenomena"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/molecular_biology> # Molecular Biology
    a schema:Intangible ;
    schema:name "Molecular Biology"@en ;
    schema:name "Molecular biology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/molecular_biology_methods> # Molecular Biology - methods
    a schema:Intangible ;
    schema:name "Molecular Biology - methods"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/natural_science_disciplines> # Natural Science Disciplines
    a schema:Intangible ;
    schema:name "Natural Science Disciplines"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/phenomena_and_processes> # Phenomena and Processes
    a schema:Intangible ;
    schema:name "Phenomena and Processes"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/poisoning_metabolism> # Poisoning - metabolism
    a schema:Intangible ;
    schema:name "Poisoning - metabolism"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/poisons_metabolism> # Poisons - metabolism
    a schema:Intangible ;
    schema:name "Poisons - metabolism"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/specialty_uses_of_chemicals> # Specialty Uses of Chemicals
    a schema:Intangible ;
    schema:name "Specialty Uses of Chemicals"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/substance_related_disorders> # Substance-Related Disorders
    a schema:Intangible ;
    schema:name "Substance-Related Disorders"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/toxicology_&_public_health> # Toxicology & Public Health
    a schema:Intangible ;
    schema:name "Toxicology & Public Health"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4479764439#Topic/toxicology_methods> # Toxicology - methods
    a schema:Intangible ;
    schema:name "Toxicology - methods"@en ;
    .

<http://worldcat.org/isbn/9780470285244>
    a schema:ProductModel ;
    schema:isbn "0470285249" ;
    schema:isbn "9780470285244" ;
    .

<http://worldcat.org/isbn/9780470285251>
    a schema:ProductModel ;
    schema:isbn "0470285257" ;
    schema:isbn "9780470285251" ;
    .

<http://worldcat.org/isbn/9781118679722>
    a schema:ProductModel ;
    schema:isbn "1118679725" ;
    schema:isbn "9781118679722" ;
    .

<http://worldcat.org/isbn/9781281732507>
    a schema:ProductModel ;
    schema:isbn "1281732508" ;
    schema:isbn "9781281732507" ;
    .

<http://worldcat.org/isbn/9786611732509>
    a schema:ProductModel ;
    schema:isbn "6611732500" ;
    schema:isbn "9786611732509" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.