skip to content
Molecular and Cell Biology of Pain Preview this item
ClosePreview this item
Checking...

Molecular and Cell Biology of Pain

Author: Theodore J Price; Greg Dussor
Publisher: Waltham, Massachusetts : Academic Press, 2015. ©2015
Series: Progress in molecular biology and translational science, v. 131.
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Molecular and cell biology of pain.
Waltham, Massachusetts : Academic Press, ©2015
xviii, 630 pages
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Theodore J Price; Greg Dussor
ISBN: 9780128014325 0128014326
OCLC Number: 905920725
Language Note: Text in English.
Description: 1 online resource (663 pages, 14 unnumbered pages of plates) : illustrations (some color).
Contents: Front Cover; Molecular and Cell Biology of Pain; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Pain Pathways and Pain T̀̀argets;́́ 1. An Introduction to Pain and Pain Pathways; 1.1. Neuropathic pain; 1.2. Inflammatory Pain; 2. Ion Channels, Receptors, and Other T̀̀argets ́́for Persistent Inflammatory or Neuropathic Pain; 2.1. Ion channels; 2.2. Sodium channels; 2.3. Calcium channels; 2.4. K+ channels; 2.5. Receptors; 2.6. Purinergic receptors; 2.7. Toll-like receptors; 2.8. PAR receptors; 2.9. Glutamate receptors; 2.10. AMPA receptors; 2.11. NMDA receptors. 2.12. Metabotropic glutamate receptors2.13. Opioid receptors; 2.14. TRPV receptors; 2.15. Prostaglandin (prostanoid) E2; 2.16. Pronociceptive neurotransmitters; 2.16.1. Nitric oxide; 2.16.2. Nerve growth factor; 3. Summary; Acknowledgments; References; Chapter 2: Peripheral Scaffolding and Signaling Pathways in Inflammatory Pain; 1. Introduction; 2. Inflammatory Mediators; 2.1. Bradykinin receptor; 2.2. Prostaglandin receptor; 2.3. Serotonin receptor; 2.4. Purinergic receptors; 2.5. Receptor tyrosine kinases; 2.6. Neurokinin receptor; 2.7. Glutamate receptors. 2.8. Protease-activated receptors2.9. Calcitonin receptor-like receptor and receptor activity-modifying protein 1; 2.10. Endothelin receptors; 3. Signaling Mechanisms; 4. Scaffolding Structures; 4.1. A-kinase anchoring protein 79/150; 4.2. <U+00dd>-Arrestin; 5. Concluding Remarks; References; Chapter 3: Contribution of Mechanosensitive Ion Channels to Somatosensation; 1. The Evolution of Mechanosensing; 2. MSCs in Nociceptors; 3. Difficulties in Identifying Genes Encoding MSCs; 3.1. Piezo2 as a mechanosensitive channel in sensory neurons; 4. Gating Mechanisms of MSCs. 5. Role of MSCs in the Transmission of Noxious Mechanical Inputs6. Sensitization of MSCs Is Necessary for the Induction of Mechanical Allodynia; 7. Potassium-Selective MSCs in Nociceptors; References; Chapter 4: Sensory TRP Channels: The Key Transducers of Nociception and Pain; 1. Introduction; 2. Ion Channels in the TRPV Subfamily; 2.1. Transient receptor potential vanilloid 1; 2.1.1. Expression and distribution in nervous system; 2.1.2. Structure; 2.1.3. Functional properties of the channel; 2.1.4. Modulation of channel expression and function; 2.1.5. Channel desensitization. 2.1.6. Involvement in pain conditions2.1.7. Involvement in other physiological and pathological conditions; 2.1.8. Drug development targeting TRPV1; 2.2. Transient receptor potential vanilloid 2, 3, and 4; 3. Ion Channels in the TRPM Subfamily; 3.1. Transient receptor potential melastatin 3; 3.2. Transient receptor potential melastatin 8; 3.2.1. Expression and distribution in nervous system; 3.2.2. Structure; 3.2.3. Functional properties of the channel; 3.2.4. Modulation of channel expression and function; 3.2.5. Involvement in pain conditions; 3.2.6. Drug development targeting TRPM8.
Series Title: Progress in molecular biology and translational science, v. 131.
Responsibility: edited by Theodore J. Price, Greg Dussor.

Abstract:

Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. <ul><li>Written by future leaders in the pain field</li><li>Covers a wide range of targets</li><li>Contains provocative i.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/905920725> # Molecular and Cell Biology of Pain
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
    library:oclcnum "905920725" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/mau> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_clinical_medicine> ; # MEDICAL--Clinical Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/health_&_fitness_diseases_general> ; # HEALTH & FITNESS--Diseases--General
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_diseases> ; # MEDICAL--Diseases
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_internal_medicine> ; # MEDICAL--Internal Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/nociceptors> ; # Nociceptors
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_evidence_based_medicine> ; # MEDICAL--Evidence-Based Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/2827723855#Topic/pain_molecular_aspects> ; # Pain--Molecular aspects
    schema:about <http://dewey.info/class/616.0472/e23/> ;
    schema:bookEdition "First edition." ;
    schema:bookFormat schema:EBook ;
    schema:copyrightYear "2015" ;
    schema:datePublished "2015" ;
    schema:description "Front Cover; Molecular and Cell Biology of Pain; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Pain Pathways and Pain T̀̀argets;́́ 1. An Introduction to Pain and Pain Pathways; 1.1. Neuropathic pain; 1.2. Inflammatory Pain; 2. Ion Channels, Receptors, and Other T̀̀argets ́́for Persistent Inflammatory or Neuropathic Pain; 2.1. Ion channels; 2.2. Sodium channels; 2.3. Calcium channels; 2.4. K+ channels; 2.5. Receptors; 2.6. Purinergic receptors; 2.7. Toll-like receptors; 2.8. PAR receptors; 2.9. Glutamate receptors; 2.10. AMPA receptors; 2.11. NMDA receptors."@en ;
    schema:description "Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology.

Related Entities

<http://experiment.worldcat.org/entity/work/data/2827723855#Person/dussor_greg> # Greg Dussor
    a schema:Person ;
    schema:familyName "Dussor" ;
    schema:givenName "Greg" ;
    schema:name "Greg Dussor" ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Person/price_theodore_j> # Theodore J. Price
    a schema:Person ;
    schema:familyName "Price" ;
    schema:givenName "Theodore J." ;
    schema:name "Theodore J. Price" ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Series/progress_in_molecular_biology_and_translational_science> # Progress in molecular biology and translational science ;
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/905920725> ; # Molecular and Cell Biology of Pain
    schema:name "Progress in molecular biology and translational science ;" ;
    schema:name "Progress in Molecular Biology and Translational Science ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Topic/health_&_fitness_diseases_general> # HEALTH & FITNESS--Diseases--General
    a schema:Intangible ;
    schema:name "HEALTH & FITNESS--Diseases--General"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_clinical_medicine> # MEDICAL--Clinical Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Clinical Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_diseases> # MEDICAL--Diseases
    a schema:Intangible ;
    schema:name "MEDICAL--Diseases"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_evidence_based_medicine> # MEDICAL--Evidence-Based Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Evidence-Based Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Topic/medical_internal_medicine> # MEDICAL--Internal Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Internal Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/2827723855#Topic/pain_molecular_aspects> # Pain--Molecular aspects
    a schema:Intangible ;
    schema:name "Pain--Molecular aspects"@en ;
    .

<http://worldcat.org/entity/work/data/2827723855#CreativeWork/molecular_and_cell_biology_of_pain>
    a schema:CreativeWork ;
    rdfs:label "Molecular and cell biology of pain." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/905920725> ; # Molecular and Cell Biology of Pain
    .

<http://worldcat.org/isbn/9780128014325>
    a schema:ProductModel ;
    schema:isbn "0128014326" ;
    schema:isbn "9780128014325" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.