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Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

Author: Igor B Roninson
Publisher: Boston, MA : Springer US, 1991.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
1 Characteristics of Multidrug Resistance in Human Tumor Cells.- 2 Development of Multidrug Resistance in Rodent Cell Lines.- 3 Cloning and Characterization of Mouse mdr Genes.- 4 Isolation and Characterization of the Human MDR (P-Glycoprotein) Genes.- 5 Amplification of Several Different Genes in Multidrug-Resistant Chinese Hamster Cell Lines.- 6 Molecular and Cytogenetic Analysis of Multidrug Resistance-Associated  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Igor B Roninson
ISBN: 9781461537946 1461537940
OCLC Number: 851800763
Description: 1 online resource (xviii, 406 pages)
Contents: 1 Characteristics of Multidrug Resistance in Human Tumor Cells --
2 Development of Multidrug Resistance in Rodent Cell Lines --
3 Cloning and Characterization of Mouse mdr Genes --
4 Isolation and Characterization of the Human MDR (P-Glycoprotein) Genes --
5 Amplification of Several Different Genes in Multidrug-Resistant Chinese Hamster Cell Lines --
6 Molecular and Cytogenetic Analysis of Multidrug Resistance-Associated Gene Amplification in Chinese Hamster, Mouse Sarcoma, and Human Neuroblastoma Cells --
7 Karyotype and Amplicon Evolution during Stepwise Development of Multidrug Resistance in Djungarian Hamster Cell Lines --
8 Chromosome Localization of P-Glycoprotein Genes in Drug-Sensitive and -Resistant Human Cells --
9 Structure and Evolution of P-Glycoproteins --
10 Drug Accumulation and Binding in P-Glycoprotein-Associated Multidrug Resistance --
11 Binding of Drugs and ATP by P-Glycoprotein and Transport of Drugs by Vesicles from Human Multidrug-Resistant Cells --
12 Protein Changes in Multidrug-Resistant Cells --
13 Membrane Lipids of Multidrug-Resistant Cells: Chemical Composition and Physical State --
14 Expression of the MDR1 Gene in Normal Human Tissues --
15 Expression of the Multidrug Resistant Gene in Human Cancer --
16 Immunohistochemical Analysis of P-Glycoprotein Expression in Normal and Tumor Tissues in Humans --
17 Quantitative Estimation of MDR1 mRNA Levels by Polymerase Chain Reaction --
18 Collateral Sensitivity of Multidrug-Resistant Cells --
19 Reversal of Multidrug Resistance by Calcium Channel Blockers and Other Agents --
20 Growth Inhibition of Multidrug-Resistant Cells by Monoclonal Antibodies against P-Glycoprotein --
21 P-Glycoprotein-Mediated Drug Resistance: Puzzles and Perspectives.
Responsibility: edited by Igor B. Roninson.

Abstract:

This type of resistance, known as multidrug or pleiotropic drug resistance, is characterized by cross-resistance of cells to several different classes of cytotoxic drugs, including some of the most  Read more...

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