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Molecular basis for therapy of AIDS-defining cancers

Author: Dirk Peter Dittmer; Susan E Krown
Publisher: New York : Springer, ©2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
An increased risk for various cancers is a characteristic of people living with HIV infection. Although only three cancers - Kaposi's sarcoma, high-grade B-cell lymphomas, and invasive cervical cancer - are considered to be "AIDS-defining" conditions, are associated with oncogenic viruses, and occur with increased frequency as immune function declines, other cancer types also occur significantly more frequently in  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Molecular basis for therapy of AIDS-defining cancers.
New York : Springer, ©2010
(OCoLC)436030992
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Dirk Peter Dittmer; Susan E Krown
ISBN: 9781441915139 1441915133
OCLC Number: 654380123
Description: 1 online resource (xiii, 256 pages) : illustrations
Contents: Cover13; --
Foreword --
Contents --
Contributors --
The Epidemiology of Cancer in People with HIV --
Kaposis Sarcoma --
Kaposi's Sarcoma in the Pre-HAART Era --
Kaposi's Sarcoma in the HAART Era --
Non-Hodgkin Lymphoma --
HIV-Associated NHL Since the Introduction of HAART --
Cervical Cancer --
Anal Cancer --
Hodgkin Lymphoma --
HPV-Related Anogenital and Head and Neck Cancers --
Conjunctival Cancer --
Liver Cancer --
Lung Cancer --
Non-melanoma Skin Cancer --
Conclusion --
References --
Epidemiology and Clinical Characteristicsof Non-AIDS-Defining Malignancies --
Introduction --
Epidemiology --
Studies Comparing the Pre-HAART Era and the HAART Era --
Studies Linking Risk of Cancer to Level of Immunosuppression --
The Effect of Interrupted Antiretroviral Therapy on the Risk of Cancers --
Meta-analysis Comparing HIV-Infected Individuals to Solid Organ Transplant Recipients --
Hodgkin Disease --
Clinical Presentation of HL --
Treatment of HL --
Chemotherapy and HAART --
Anal Cancer --
Clinical Features of Anal Cancer --
Anal Cancer Treatment and Outcomes --
Screening for Anal Cancer --
Effect of HAART on Anal Dysplasia --
Lung Cancer --
The Effect of HAART on the Incidence of Lung Cancer --
Contribution of Smoking Tobacco to Risk of HIV-Related Lung Cancer --
Clinical Characteristics of HIV-Positive Patients with Lung Cancer --
Treatment and Outcomes of Lung Cancer in the HAART Era --
Conclusions --
References --
HIV-Related Cancer Management in Resource-Limited Settings: A Case Study of Malawi --
Overview of Malawi Health-Care System --
HIV in Malawi --
Cancer in Malawi --
Surveillance --
HIV-Related Malignancies in Malawi --
Prevention and Early Detection --
Treatment and Management --
Treatment --
Palliative Care --
Treatment of Common HIV-Related Malignancies in Malawi --
Strategies for Improving HIV-Related Malignancy Care --
Surveillance --
Prevention --
Treatment --
Training --
Partnerships --
Research --
Summary --
References --
Immunology of HIV-Associated Kaposi Sarcoma --
Introduction --
Immunity and Cancer --
Murine Models --
Evidence for the Role of Immunity in Cancer Surveillance in Humans --
Kaposi Sarcoma --
Impact of HIV-Related Immunodeficiency on the Development of KS --
Other Factors Affecting KS Risk --
Host Factors --
Environmental Factors --
Viral Factors --
Highly Active Antiretroviral Therapy (HAART) and Immune Reconstitution --
Quantitative and Qualitative HAART-Associated Immune Reconstitution --
HAART and KS --
HAART-Associated Anti-HHV-8 Immune Reconstitution --
HAART Effects on KS Independent of Anti-HHV-8 Immune Reconstitution --
KS Development and Persistence Despite HAART --
Immune Reconstitution Inflammatory Syndrome (IRIS) --
IRIS and Cancer --
Conclusion --
References --
Targeting Signal Transduction Pathways for the Treatment of Kaposi Sarcoma --
Introduction --
Biology of Kaposi Sarcoma --
Therapeutic Opportunities --
Summary --
References --
Role of NF-B Inhibitors in HIV-Related Malignancies --
The NF-B Pathway Is Central to Cell Survival --
NF-B in Cancer --
HIV/AIDS and Malignancies --
NF-B in AIDS-Associated Viral Oncogenesis --
Gamma Herpesviruses and NF-B --
Murine Gamma Herpesvirus 68 (MHV-68) --
Kaposis Sarc.
Responsibility: Dirk P. Dittmer, Susan E. Krown, editors.

Abstract:

Cancer incidences increase in people living with HIV/AIDS. This book provides an update of the latest treatments for AIDS defining cancers. It updates scientific rationale for established treatments  Read more...

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