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Molecular biology of aging

Author: Leonard Guarente; Linda Partridge; Douglas C Wallace
Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, ©2008.
Series: Cold Spring Harbor monograph series, 51.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.
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Genre/Form: Aufsatzsammlung
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Leonard Guarente; Linda Partridge; Douglas C Wallace
ISBN: 9780879698249 0879698241
OCLC Number: 164802911
Description: viii, 610 pages : illustrations (some color) ; 24 cm.
Contents: The human mitochondrion and pathophysiology of aging and age-related diseases / D.C. Wallace --
Sirtuins : a universal link between NAD, metabolism, and aging / S.-i. Imai and L.P. Guarente --
Calorie restriction in lower organisms / S.L. Helfand, J.H. Bauer, and J.G. Wood --
Evolutionary theory in aging research / S.N. Austad and T.B.L. Kirkwood --
An overview of the biology of aging : a human perspective / G.M. Martin and C.E. Finch --
p53, cancer, and longevity / L.A. Donehower and A.J. Levine --
Aging processes in caenorhabditis elegans / H.A. Tissenbaum and T.E. Johnson --
Cellular senescence : a link between tumor suppression and organismal aging? / J.M. Sedivy, U.M. Munoz-Najar, J.C. Jeyapalan, and J. Campisi --
Genome-wide views of aging gene networks / S.K. Kim --
Aging in mammalian stem cells and other self-renewing compartments / D.J. Rossi and N.E. Sharpless --
Yeast, a feast : the fruit fly Drosophila as a model organism for research into aging / L. Partridge and J. Tower --
DNA repair and aging / V.A. Bohr [and others] --
Extended life span in mice with reduction in the GH/IGF-1 axis / J.J. Kopchick, A. Bartke, and D.E. Berryman --
Alzheimer's disease : genetics, pathogenesis, models, and experimental therapeutics / P.C. Wong [and others] --
How does caloric restriction increase the longevity of mammals? / R. Weindruch . [and others] --
Determination of aging rate by coordinated resistance to multiple forms of stress / G.J. Lithgow and R.A. Miller --
Molecular mechanisms of aging : insights from budding yeast / S.-J. Lin and D. Sinclair --
Genetics of exceptional longevity / T.T. Perls and P. Sebastiani --
Mammalian metabolism in aging / P. Puigserver and C.R. Kahn --
Telomeres and telomerase in aging and cancer / J.W. Shay and W.E. Wright.
Series Title: Cold Spring Harbor monograph series, 51.
Responsibility: edited by Leonard P. Guarente, Linda Partridge, Douglas C. Wallace.

Abstract:

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

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